Special Issue on "Marine Alkaloids" of the Marine Drugs journal

(To be added)

Anake Kijjoa ^1,2,*, Rawiwan Wattanadilok ^2,3, Nair Campos ², Maria São José Nascimento ⁴, Madalena Pinto ⁴ and Werner Herz ⁵
1 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand
4 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farmácia, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal
5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA
* Author to whom correspondence should be addressed; Email: [email protected]
Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007
Full Original Paper: Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5, 6-22 (PDF format 126 K)


Gerhard Bringmann ^1,*, Tobias A. M. Gulder ¹, Gerhard Lang ^1,2, Stefanie Schmitt ¹, Rüdiger Stöhr ², Jutta Wiese ², Kerstin Nagel ² and Johannes F. Imhoff ^2,*
1 Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany
2 Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany
* Authors to whom correspondence should be addressed; G.B. Tel. +49-931-8885323, Fax +49-931-8884755, E-mail: [email protected]; J.F.I. Tel. +49-431-6004450, Fax +49-431-6004452, E-mail: [email protected]
Dedicated to Prof. Dr. W.E.G. Müller on the occasion of his 65th birthday
Received: 29 May 2007/ Accepted: 21 June 2007 / Published: 25 June 2007
Full Original Paper: Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Mar. Drugs 2007, 5, 23-30 (PDF format 89 K)


Baoquan Bao ^1,2, Ping Zhang ¹, Yoonmi Lee ¹, Jongki Hong ³, Chong-O. Lee ⁴ and Jee H. Jung ^1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea
2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China; E-mail: [email protected]
3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea
4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed. Tel., 82-51-510-2803; Fax: 82-51-513-6754; E-mail: [email protected]
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
Full Original Paper: Monoindole Alkaloids from a Marine Sponge Spongosorites sp.
Mar. Drugs 2007, 5, 31-39 (PDF format 118 K)

Jaine H. H. L. de Oliveira ¹, Mirna H. R. Seleghim ¹, Christoph Timm ², Achim Grube ², Matthias Köck ², Gislene G.F. Nascimento ³, Ana Claudia T. Martins ³, Elissa G. O. Silva ³, Ana Olívia de Souza ⁴, Fabio C. S. Galetti ⁴, Paulo R. R. Minarini ⁴, Célio L. Silva ⁴, Eduardo Hajdu ⁵ and Roberto G. S. Berlinck ^1,*
1 Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
E-mail: [email protected] for Jaine H. H. L. de Oliveira; E-mail: [email protected] for Mirna H. R. Seleghim
2 Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12,D-27570 Bremerhaven, Germany.
E-mail: [email protected] for Achim Grube;E-mail: [email protected] for Matthias Köck
3 Faculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracaba, SP, Brazil.
E-mail: [email protected] for Gislene G.F. Nascimento
4 Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil.
E.mail: olí[email protected] for Ana Olívia de Souza
5 Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
E-mail: [email protected] for Fabio C. S. Galetti
6 Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil.
E-mail: [email protected] for Eduardo Hajdu
* Author to whom correspondence should be addressed; E-mail: [email protected]
Full Original Paper: Antimicrobial and Antimycobacterial Activity of Cyclostelletamine Alkaloids from Sponge Pachychalina sp.
Mar. Drugs 2006, 4, 1-8 (PDF format 50 K)


Susan Wonnacott ^1,* and Timothy Gallagher ²
1 Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
E-mail: [email protected]
2 School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom
E-mail: [email protected]
* Author to whom correspondence should be addressed.
Review: The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors
Mar. Drugs 2006, 4, 228-254 (PDF format 186 K)


William Kem ^1,*, Ferenc Soti ¹, Kristin Wildeboer ¹, Susan LeFrancois ¹, Kelly MacDougall ¹, Dong-Qing Wei ³, Kuo-Chen Chou ⁴ and Hugo R. Arias ²
1 Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610-0267, USA
2 Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766-1854, USA
3 College of Life Science and Technology, Shanghai Jiaotong University, Minhang District Shanghai, 200240, China
4 Gordon Life Science Institute, San Diego, CA 92130, USA
* Authors to whom correspondence should be addressed; Tel. (352) 392-3541; Fax (352) 392-9696; Email: [email protected]
Review: The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
Mar. Drugs 2006, 4, 255-273 (PDF format 210 K)

Hamad H. Issa,^a,b Junichi Tanaka,*^,a Rachmaniar Rachmat,^c Andi Setiawan,^d Agus Trianto,^e and Tatsuo Higa ^a
a Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan
b Department of Sciences, School of Education, Arts and Sciences, The State University of Zanzibar, P.O.Box 146, Zanzibar, Tanzania
c Research and Development Centre for Oceanology LIPI, Jl. Pasir Putih 1, Ancor Timur, Jakarta 11048, Indonesia
d Department of Chemistry, Lampung University, Bandar Lampung 35145, Indonesia
e Department of Marine Science, Diponegoro University, Semarang, Central Java 50234, Indonesia
*Corresponding author. Tel/Fax: 81-98-895-8560; e-mail: [email protected]
Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian
Mar. Drugs 2005, 3, 78-83 (PDF format 44 K)

Makoto Kuramoto¹, Hirokazu Arimoto² and Daisuke Uemura^2,*

1 Department of Material Science, Integrated Center for Science, Ehime University, Bunkyou-chou 2-5, Matsuyama 790-8577, Japan

2 Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan
* Author to whom correspondence should be addressed; Tel. 081-52-7893654, Fax 081-52-7893654, E-mail: [email protected]

Review: Bioactive Alkaloids from the Sea
Mar. Drugs 2004, 2, 39-54 (PDF format 131 K)

Wafaa Hassan,^1,3 RuAngelie Edrada,¹ Rainer Ebel,¹ Victor Wray² and Peter Proksch^1,*

¹ Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, Geb. 26.23,

40225 Düsseldorf, Germany. Fax: +49/211-8111923. E-mail: [email protected]

² Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1,  38124 Braunschweig, Germany

³ Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Full Original Paper: New Alkaloids from the Mediterranean Sponge Hamigera hamigera 

Mar. Drugs 2004, 2, 88-100 (PDF format 180 K)

Rohan A. Davis ¹, Lane V. Christensen ¹, Adam D. Richardson ¹, Rosana Moreira da Rocha ² and Chris M. Ireland ^1,*
1 Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA, Tel. 1 801 581 8305, Fax: 1 801 585 6208, E-mail: [email protected]
2 Universidade Federal do Paraná, Departamento de Zoologia, C.P. 19020, 81.531-980, Curitiba, Brazil

Full Original Paper: Rigidin E, a New Pyrrolopyrimidine Alkaloid from a Papua New Guinea Tunicate Eudistoma species
Mar. Drugs 2003, 1, 27-33 (PDF format 66 K)