Derek McPhee
Molecular Diversity Preservation International (MDPI), Matthaeusstrasse 11, Basel CH-4057 Switzerland; Tel. +41 79 322 3379, Fax: +41 61 302 8918, E-mail: [email protected]
Received: 29 February 2008 / Published: 1 March 2008
Editor's Note: Withdrawn Paper: Antibacterial Effect of Five Zingiberaceae Essential Oils by Laohakunjit et al., Molecules 2007, 12, 2047-2060
Molecules 2008, 13, 488-489 (PDF format 20 K)


Zhenlin Xu ¹, Youhui Yang ¹, Yueming Jiang ², Yuanming Sun ^1,*, Yudong Shen ¹ and Jie Pang ^1,3
1 College of Food Science, South China Agricultural University, Guangzhou 510642, P. R. China; E-mails: [email protected]; [email protected]; [email protected]
2 South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P. R. China; E-mail: [email protected]
3 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, R. China; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 16 January 2008; in revised form: 20 February 2008 / Accepted: 20 February 2008 / Published: 1 March 2008
Full Paper: Synthesis and Characterization of Konjac Glucomannan-Graft-Polyacrylamide via γ-Irradiation
Molecules 2008, 13, 490-500 (PDF format 301 K)
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Jana Tomaščiková ¹, Ján Imrich ^1,*, Ivan Danihel ¹, Stanislav Böhm ², Pavol Kristian ¹, Jana Pisarčíková ¹, Marián Sabol ³ and Karel D. Klika ⁴
1 Institute of Chemistry, Faculty of Science, P. J. Šafárik University, SK-041 67 Košice, Slovak Republic
2 Department of Organic Chemistry, Institute of Chemical Technology, Prague, CZ-166 28 Prague 6, Czech Republic
3 Institute of Medical and Clinical Microbiology, Faculty of Medicine, P. J. Šafárik University, SK-040 66 Košice, Slovak Republic
4 Department of Chemistry, University of Turku, FIN-20014 Turku, Finland
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 19 February 2008; in revised form: 27 February 2008 / Accepted: 27 February 2008 / Published: 1 March 2008
Full Paper: Regioselectivity and Tautomerism of Novel Five-Membered Ring Nitrogen Heterocycles Formed via Cyclocondensation of Acylthiosemicarbazides
Molecules 2008, 13, 501-518 (PDF format 121 K)


Ana L. Simplício ^1,2,*, John M. Clancy ³ and John F. Gilmer ³
1 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal
2 IBET, Apartado 12, 2781-901 Oeiras, Portugal
3 School of Pharmacy, Trinity College, Dublin 2, Ireland; E-mails: [email protected]; [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 14 December 2007; in revised form: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
Review: Prodrugs for Amines
Molecules 2008, 13, 519-547 (PDF format 165 K)
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Min Chen ^1,*, Xiumei Xu ^2,3, Zhihua Liao ², Li Dong ², Lei Li ² and Chengzhi Huang ⁴
1 School of Pharmacy, Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Southwest University, Chongqing 400715, P.R. China
2 Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Sciences, Southwest China Normal University S Chongqing 400715, P.R. China; E-mails: [email protected] (Xu); [email protected] (Liao); [email protected] (Dong); [email protected] (Li)
3 School of Life Sciences, Linyi Normal University, Linyi, Shandong Province, 276005, P.R. China
4 CQKL-LRTA, School of Pharmacy, Southwest University, Chongqing 400715, P.R. China; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: (+86)2368251225; Fax: (+86)68251225.
Received: 30 January 2008; in revised form: 28 February 2008 / Accepted: 29 February 2008 / Published: 3 March 2008
Full Paper: Neglschisandrins A-B: Two New Dibenzocyclooctene Lignans from Schisandra neglecta
Molecules 2008, 13, 548-555 (PDF format 152 K)


Huanan Hu ^1,2,3, Anjiang Zhang ^3,4,*, Lisheng Ding ^1,*, Xinxiang Lei ³ and Lixue Zhang ³
1 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China
2 Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China
3 College of Chemistry and Material Engineering, Wenzhou University, Wenzhou 325027, P. R. China
4 Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China
* Authors to whom correspondence should be addressed; E-mails: [email protected]; [email protected]; Tel: (+86) 574 86685127; Fax: (+86) 574 87912309.
Received: 9 November 2007; in revised form: 13 February 2008 / Accepted: 20 February 2008/ Published: 3 March 2008
Full Paper: Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)-4-Alkyl-1H-[1,2,3]-Triazoles
Molecules 2008, 13, 556-566 (PDF format 124 K)


Carmen Limban ¹, Mariana-Carmen Balotescu Chifiriuc ^2,*, Alexandru-Vasile Missir ¹, Ileana Cornelia Chiriţă ¹ and Coralia Bleotu ³
1 Pharmaceutical Chemistry Department, Faculty of Farmacy, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, sect. 2, 020956, Bucharest, Romania; E-mails: [email protected] (Carmen Limban, Cornelia Chirita, Alexandru Vasile Missir)
2 Microbiology-Immunology Department, Faculty of Biology, University of Bucharest, Ale. Portocalelor 1-3, sect. 5, Bucharest, Romania; E-mail: [email protected] (Mariana-Carmen Balotescu Chifiriuc)
3 Institute of Virology “Prof. St. Nicolau”, Sos. M. Bravu, 36, sect.2, Bucharest, Romania; E-mail: [email protected] (Coralia Bleotu)
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 29 January 2008; in revised form: 29 February 2008 / Accepted: 29 February 2008 / Published: 4 March 2008
Full Paper: Antimicrobial Activity of Some New Thioureides Derived from 2-(4-Chlorophenoxymethyl)benzoic Acid
Molecules 2008, 13, 567-580 (PDF format 316 K)


Aline Lamien-Meda ^1,*, Charles Euloge Lamien ^1,2, Moussa M.Y. Compaoré ¹, Roland N.T. Meda ¹, Martin Kiendrebeogo ¹, Boukare Zeba ¹, Jeanne F. Millogo ³ and Odile G. Nacoulma ¹
1 Laboratoire de Biochimie et de Chimie Appliquées, U.F.R/S.V.T, Université de Ouagadougou, 03 BP 7021 Ouaga 03, Burkina Faso; E-mails: [email protected] (M.M.Y.C.); [email protected] (R.N.T.M.); [email protected] (M.K.); [email protected] (B.Z.); [email protected] (O.G.N.)
2 Animal Production Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA, Vienna, Austria; E-mail: [email protected] (C.E.L.)
3 Laboratoire de Biologie et d’Ecologie Végétales, U.F.R/S.V.T, Université de Ouagadougou, 03 BP 7021 Ouaga 03, Burkina Faso; E-mail: [email protected]  (J.F.M.)
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 28 January 2008; in revised form: 4 March 2008 / Accepted: 5 March 2008 / Published: 6 March 2008
Full Paper: Polyphenol Content and Antioxidant Activity of Fourteen Wild Edible Fruits from Burkina Faso
Molecules 2008, 13, 581-594 (PDF format 125 K)


Takayuki Ogi ^1,2, Junsei Taira ³, Palupi Margiastuti ¹ and Katsuhiro Ueda ^1,*
1 Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho Okinawa 903-0123, Japan
2 Okinawa Industrial Technology Center, Uruma-shi Okinawa 904-2234, Japan; E-mail: [email protected]; Tel: (+81)-98-929-0120, Fax: (+81)-98-929-0115
3 Department of Bioresources Engineering, Okinawa National College of Technology, Nago-shi Okinawa 905-2192, Japan; E-mail: [email protected]; Tel: (+81)-980-55-4207; Fax: (+81)-980-55-4012
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: (+81)-98-895-8894; Fax: (+81)-98-895-8565.
Received: 20 February 2008; in revised form: 8 March 2008 / Accepted: 9 March 2008 / Published: 11 March 2008
Communication: Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
Molecules 2008, 13, 595-602 (PDF format 114 K)


Sanda P. Dilber ¹, Silva Lj. Dobric ², Zorica D. Juranic ³, Bojan D. Markovic ¹, Sote M. Vladimirov ¹ and Ivan O. Juranic ^4,*
1 Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia
2 Institute for Scientific Information, Crnotravska 17, 11000 Belgrade, Serbia
3 Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia
4 Faculty of Chemistry, University of Belgrade, P.O. Box 158, 11001 Belgrade, Serbia
* Author to whom the correspondence should be addressed; E-mail: [email protected]
Received: 18 February 2008; in revised form: 8 March 2008/ Accepted: 10 March 2008 / Published: 18 March 2008
Full Paper: Docking Studies and Anti-inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids
Molecules 2008, 13, 603-615 (PDF format 114 K)


Man Chin Chung ^1,*, Elizabeth Igne Ferreira ^2,†, Jean Leandro Santos ^l,2, Jeanine Giarolla ², Daniela Gonçales Rando ², Adélia Emília Almeida ¹, Priscila Longhin Bosquesi ¹, Renato Farina Menegon ¹ and Lorena Blau ¹
1 Lapdesf - Laboratório de Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas - UNESP Rodovia Araraquara-Jaú Km 1,
14801-902, Brazil
2 LAPEN – Laboratório de Planejamento e Síntese de Quimioterápicos Potencialmente Ativos em Endemias Tropicais, Departamento de Farmácia, Faculdade de Ciências Farmacêuticas – USP/SP, R. Prof. Lineu Prestes, 580, B-13S, Cidade Universitária, São Paulo, 05508-900, Brazil; † E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 11 January 2008; in revised form: 12 March 2008 / Accepted: 12 March 2008 / Published: 19 March 2008
Review: Prodrugs for the Treatment of Neglected Diseases
Molecules 2008, 13, 616-677 (PDF format 462 K)
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Giuseppe A. Consiglio, Salvatore Failla and Paolo Finocchiaro*
Dipartimento di Metodologie Fisiche e Chimiche per l`Ingegneria, Università di Catania, Viale A. Doria, 6-95125-Catania Italy; E-mails: [email protected] (Giuseppe A. Consiglio);
[email protected] (Salvatore Failla); [email protected] (Paolo Finocchiaro)
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 25 February 2008; in revised form: 14 March 2008 / Accepted: 16 March 2008 / Published: 20 March 2008
Review: New Cleft-like Molecules and Macrocycles from Phosphonate Substituted Spirobisindanol
Molecules 2008, 13, 678-700 (PDF format 190 K)
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Qiang Yu and Per Carlsen *
Department of Chemistry, Norwegian University of Science and Technology-NTNU, N-7491 Trondheim, Norway
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 21 February 2008 / Accepted: 10 March 2008 / Published: 26 March 2008
Full Paper: Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone
Molecules 2008, 13, 701-715 (PDF format 158 K)

Salvador Gil, Margarita Parra* and Pablo Rodríguez
Department de Organic Chemistry, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain; Fax +34(9)63543831; E-mails: [email protected]; [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 10 March 2008; in revised form: 26 March 2008 / Accepted: 26 March 2008 / Published: 27 March 2008
Full Paper: An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity
Molecules 2008, 13, 716-728 (PDF format 75 K)


Tong Fei Zhu ^1,2, Kai Yi Huang ², Xu Ming Deng ^1,*, Yu Zhang ², Hua Xiang ¹, Hui Yuan Gao ² and Da Cheng Wang ^1,*
1 College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P. R. China
2 School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China; E-mail: [email protected] (Zhu)
*Author to whom correspondence should be addressed; E-mail: [email protected]; [email protected]; Fax: (+86)-431-87836160
Received: 2 February 2008 / Accepted: 24 March 2008 / Published: 27 March 2008
Full Paper: Three New Caffeoyl Glycosides from the Roots of Picrorhiza Scrophulariiflora
Molecules 2008, 13, 729-735 (PDF format 75 K)


Oztekin Algul ^1,*, Andre Kaessler ², Yagmur Apcin ¹, Akin Yilmaz ¹ and Joachim Jose ²
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, Mersin 33169, Turkey; Tel: (+90) 532 414 01 99; Fax: (+90) 324 341 30 22; E-mails: [email protected] (Akin Yilmaz), [email protected] (Yagmur Apcin)
2 Department of Bioanalytics, Institute for Pharmaceutical Chemistry, Heinrich-Heine University, Düsseldorf 40225, Germany; E-mails: [email protected] (Andre Kaessler), [email protected] (Joachim Jose)
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 12 February 2008; in revised form: 20 March 2008 / Accepted: 20 March 2008 / Published: 27 March 2008
Full Paper: Comparative Studies on Conventional and Microwave Synthesis of Some Benzimidazole, Benzothiazole and Indole Derivatives and Testing on Inhibition of Hyaluronidase
Molecules 2008, 13, 736-748 (PDF format 179 K)


Paolo Urbani ¹, Anna Ramunno ¹, Rosanna Filosa ¹, Aldo Pinto ¹, Ada Popolo ¹, Erminia Bianchino ¹, Stefano Piotto ¹, Carmela Saturnino ¹, Rocco De Prisco ², Barbara Nicolaus ² and Giuseppina Tommonaro ^2,*
1 Department of Pharmaceutical Sciences, University of Salerno,Via Ponte don Melillo, 84084 Fisciano, (SA) Italy; E-mails: [email protected] (P. Urbani); [email protected] (A. Ramunno); [email protected] (R. Filosa); [email protected] (A. Pinto); [email protected] (A. Popolo); [email protected] (E. Bianchino); [email protected] (S. Piotto); [email protected] (C. Saturnino)
2 Institute of Biomolecular Chemistry-CNR, Via Campi Flegrei 34, 80078 Pozzuoli, (NA) Italy; Emails: [email protected] (R. De Prisco); [email protected] (B. Nicolaus)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: +39-81-8675190; Fax: +39-81-8041770
Received: 14 February 2008; in revised form: 4 March 2008 / Accepted: 25 March 2008 / Published: 28 March 2008
Full Paper: Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis
Molecules 2008, 13, 749-761 (PDF format 212 K)


Carina C. Crucho, Krasimira T. Petrova*, Rui C. Pinto, and Maria T. Barros*
REQUIMTE, Departamento de Química - FCT, Universidade Nova de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal
* Authors to whom correspondence should be addressed. E-mails: [email protected]; [email protected]; Fax: (+)351 212948550
Received: 5 March 2008; in revised form: 26 March 2008 / Accepted: 26 March 2008 / Published: 28 March 2008
Communication: Novel Unsaturated Sucrose Ethers and Their Application as Monomers
Molecules 2008, 13, 762-770 (PDF format 142 K)


Corrigendum: Correction to Oz, H.S.; Ebersole, Jeffrey L. Application of Prodrugs to Inflammatory Diseases of the Gut. Molecules 2008, 13, 452-474
Received: 31 March 2008 / Accepted: 1 April 2008 / Published: 1 April 2008
Molecules 2008, 13, 771 (PDF format 18 K)


Julia Bensemhoun ¹, Isabelle Bombarda ¹, Maurice Aknin ², Robert Faure ¹, Jean Vacelet ³ and Emile M. Gaydou ^1,*
1 UMR CNRS 6263, Equipe Phytochimie, Institut des Sciences Moléculaires de Marseille, Université Paul Cézanne, Faculté des Sciences et Techniques de Saint-Jérôme, Avenue Escadrille Normandie Niémen, Case 461, Marseille cedex 20, France
2 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences, Université de la Réunion, 15 Avenue René Cassin, B.P. 7151, 97715, Saint-Denis, Cedex 9, Ile de la Réunion
3 Centre d’Océanologie de Marseille, Aix-Marseille Université, CNRS UMR 6540 DIMAR, Station Marine d’Endoume, 13007 Marseille, France
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +33-491288647; Fax: +33-491289324
Received: 6 February 2008; in revised form: 31 March 2008 / Accepted: 31 March 2008 / Published: 1 April 2008
Full Paper: Marine Bifunctional Sphingolipids from the Sponge Oceanapia ramsayi
Molecules 2008, 13, 772-778 (PDF format 160 K)


Karima Ighilahriz ¹, Baya Boutemeur ¹, Fariza Chami ², Cherifa Rabia ², Maâmar Hamdi ¹ and Safouane M. Hamdi ^3,*
1 Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111
Bab-Ezzouar. Alger, Algeria
2 Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria
3 Laboratoire de Biochimie-Purpan, Institut Fédératif de Biologie, CHU Toulouse 330, Avenue de Grande-Bretagne – F- 31059 Toulouse cedex 9, France
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel:+33 5 67 69 03 76; Fax:+33 5 67 69 03 77
Received: 6 February 2008; in revised form: 28 March 2008 / Accepted: 28 March 2008 / Published: 3 April 2008
Full Paper: A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones
Molecules 2008, 13, 779-789 (PDF format 160 K)


Glauco Morales*, Adrián Paredes, Patricia Sierra and Luis A. Loyola
Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Antofagasta, Chile
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: 56-55-637812; Fax: 56-55-637457
Received: 31 January 2008; in revised form: 31 March 2008 / Accepted: 31 March 2008 / Published: 6 April 2008
Communication: Antimicrobial Activity of Three Baccharis Species Used in the Traditional Medicine of Northern Chile
Molecules 2008, 13, 790-794 (PDF format 41 K)


Josip Mastelić ^1,*, Olivera Politeo ² and Igor Jerković ¹
1 Department of Organic Chemistry, Faculty of Chemistry and Technology, N. Tesle 10/V, 21000 Split, Croatia; Fax: 00385 21 329 461; E-mail: [email protected]
2 Department of Biochemistry, Faculty of Chemistry and Technology, N. Tesle 10/V, 21000 Split, Croatia; Fax: 00385 21 329 461; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 6 March 2008; in revsed form: 3 April 2008 / Accepted: 3 April 2008 / Published: 7 April 2008
Full Paper: Contribution to the Analysis of the Essential Oil of Helichrysum italicum (Roth) G. Don. – Determination of Ester Bonded Acids and Phenols
Molecules 2008, 13, 795-803 (PDF format 195 K)

Lotf A. Saghatforoush ^1,*, Ali Aminkhani ², Sohrab Ershad ³, Ghasem Karimnezhad ¹, Shahriar Ghammamy ⁴ and Roya Kabiri ⁵
1 Department of Chemistry, Payame Noor University (PNU), Khoy, Iran
2 Department of Chemistry, Islamic Azad University, Khoy Branch, Khoy, Iran
3 Department of Chemistry, Payame Noor University (PNU), Marand, Iran
4 Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
5 Faculty of Chemistry, Tabriz University, Tabriz, Iran
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 21 February 2008; in revised form: 2 April 2008 / Accepted: 6 April 2008 / Published: 8 April 2008
Full Paper: Preparation of Zinc (II) and Cadmium (II) Complexes of the Tetradentate Schiff Base Ligand 2-((E)-(2-(2-(pyridine-2-yl)-ethylthio)ethylimino)methyl)-4-bromophenol (PytBrsalH)
Molecules 2008, 13, 804-811 (PDF format 772 K)


Lakhdar Djarri ¹, Kamel Medjroubi ¹, Salah Akkal ¹, Abdelhakim Elomri ², Elisabeth Seguin ², Marie-Laure Groult ³ and Philippe Vérité ^4,*
1 Laboratoire Phytochimie et Analyses Physico-chimiques et Biologiques, Université Mentouri Constantine, Route de Aïn El Bey, 25000 Constantine, Algeria;
E-mail: [email protected]
2 Laboratoire de Pharmacognosie, UFR de Médecine et de Pharmacie UMR CNRS 6014, 22 Boulevard Gambetta F-76183 Rouen cedex 1, France; E-mail: [email protected]
3 Laboratoire de Botanique-Mycologie, UFR de Médecine et de Pharmacie, 22 Boulevard Gambetta F-76183 Rouen cedex 1, France; E-mail: [email protected]
4 Laboratoire de Chimie Analytique, UFR de Médecine et de Pharmacie ADEN 3234, 22 Boulevard Gambetta F-76183 Rouen cedex 1, France
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 29 January 2008; in revised form: 27 March 2008 / Accepted: 27 March 2008 / Published: 8 April 2008
Full Paper: Variability of Two Essential Oils of Kundmannia sicula (L.) DC., A Traditional Algerian Medicinal Plant
Molecules 2008, 13, 812-817 (PDF format 45 K)


Ibrahim Mustafa El-Deeb ¹, Jae Chun Ryu ² and So Ha Lee ^1,2,*
1 Department of Biomolecular Science, University of Science and Technology, Daejon, Korea; E-mail: [email protected]
2 Life Sciences Research Division, Korea Institute of Science & Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: (+82) 2 9586834.
Received: 26 March 2008; in revised form: 8 April 2008 / Accepted: 8 April 2008 / Published: 9 April 2008
Full Paper: Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst
Molecules 2008, 13, 818-830 (PDF format 127 K)


María Sol Shmidt, Ana María Reverdito, Lautaro Kremenchuzky, Isabel Amalia Perillo* and María Mercedes Blanco
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, República Argentina
* Author to whom correspondence should be addressed; e-mail: [email protected]
Received: 11 March 2008; in revised form: 9 April 2008 / Accepted: 9 April 2008 / Published: 10 April 2008
Full Paper: Simple and Efficient Microwave Assisted N-Alkylation of Isatin
Molecules 2008, 13, 831-840 (PDF format 112 K)


Lorena Blau ¹, Renato Farina Menegon ¹, Elizabeth Igne Ferreira ², Antonio Gilberto Ferreira ³, Elisangela Fabiana Boffo ³, Leila Aley Tavares ³, Vladimir Constantino Gomes Heleno ^3,4,* and Man-Chin Chung ^1,*
1 Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CP 502 – 14801-902, Araraquara, SP, Brazil; E-mails: [email protected]; [email protected]
2 Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CP 66083 – 05389-970, São Paulo, SP, Brazil; E-mail: [email protected]
3 Departamento de Química, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de São Carlos, CP 676 – 13565-905, São Carlos, SP, Brazil; E-mails: [email protected]; [email protected]; [email protected]
4 Núcleo de Pesquisas em Ciências Exatas e Tecnológicas – Universidade de Franca, CP 82 – 14404-600, Franca, SP, Brazil
* Authors to whom correspondence should be addressed; E-mail for V.C.G.H.: [email protected]; Phone: +55 16 37118871; Fax: +55 16 37118878; E-mail for M-C.C.: [email protected]; Phone: +55 16 33016962; Fax: +55 16 33016960.
Received: 12 March 2008; in revised form: 6 April 2008 / Accepted: 7 April 2008 / Published: 10 April 2008
Full Paper: Synthesis and Total ¹H- and ¹³C-NMR Assignment of Cephem Derivatives for Use in ADEPT Approaches
Molecules 2008, 13,  841-854 (PDF format 131 K)
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Zu-Ming Liu, Hong-Bo Wang, Xiao-Lei Zhu, Hai-Yang Tu * and Guang-Fu Yang
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P.R.China
* Author to whom correspondence should be addressed; E-mail: [email protected]; http://klpcb.ccnu.edu.cn/
Received: 6 March 2008; in revised form: 7 April 2008 / Accepted: 12 April 2008 / Published: 12 April 2008
Full Paper: Blue Organic Light-emitting Supramolecular Microfibers: The Self-assembly of a 1,2,4-Triazolo[1,5-a]pyrimidine Derivative
Molecules 2008, 13, 855-863 (PDF format 210 K)


Dong-wu Liu *, Zhi-wei Chen and Hong-zhi Xu
Analysis and Testing Center, Shandong University of Technology, 255049, Zibo, Shandong, P.R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 21 March 2008; in revised form: 6 April 2008 / Accepted: 7 April 2008 / Published: 15 April 2008
Full Paper: Effects of Leucine-enkephalin on Catalase Activity and Hydrogen Peroxide Levels in the Haemolymph of the Pacific Oyster (Crassostrea gigas)
Molecules 2008, 13, 864-870 (PDF format 165 K)


Jinyi Yang ¹, Hong Wang ¹, Yueming Jiang ², Yuanming Sun ^1,*, Ke Pan ¹, Hongtao Lei ¹, Qing Wu ¹, Yudong Shen ¹, Zhili Xiao ¹and Zhenlin Xu ¹
1 College of Food Science, South China Agricultural University, Guangzhou 510642, P. R. China; E-mails: [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]
2 South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P. R. China; Email: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 27 March 2008; in revised form: 14 April 2008 / Accepted: 14 April 2008 / Published: 17 April 2008
Full Paper: Development of an Enzyme-linked Immuno-Sorbent Assay (ELISA) Method for Carbofuran Residues
Molecules 2008, 13, 871-881 (PDF format 142 K)


Alejandro Urzúa *, Marcos C. Rezende, Carolina Mascayano and Loretta Vásquez
Facultad de Química y Biología, Casilla 40, Correo 33, Universidad de Santiago de Chile, Santiago, Chile
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: +56-2-7181155; Fax: +56-2-6812108
Received: 28 March 2008; in revised form: 16 April 2008 / Accepted: 17 April 2008 / Published: 17 April 2008
Full Paper: A Structure-Activity Study of Antibacterial Diterpenoids
Molecules 2008, 13, 882-891 (PDF format 574 K)


Vassilis E. Kouloulias ^1,* and John R. Kouvaris ²
1 Kapodistrian University, 2nd Radiology Department, Medical School, Attikon University Hospital, Rimini 1, Xaidari, Greece
2 Aretaieion University Hospital, 1st Radiology Department, Radiotherapy Unit, Athens, Greece.
* Author to whom correspondence should be addressed; E-mail: [email protected]; Fax: +302105326418
Received: 1 February 2008; in revised form: 16 April 2008 / Accepted: 16 April 2008 / Published: 18 April 2008
Review: Cytoprotective Efficacy of Amifostine Against Radiation-Induced Rectal Toxicity: Objective and Subjective Grading Scales for Radiomucositis
Molecules 2008, 13, 892-903 (PDF format 103 K)
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Supaluk Prachayasittikul ^1,*, Prasit Buraparuangsang ¹, Apilak Worachartcheewan ², Chartchalerm Isarankura-Na-Ayudhya ², Somsak Ruchirawat ³ and Virapong Prachayasittikul ^2,*
1 Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Bangkok 10110, Thailand
2 Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
3 Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand
* Authors to whom correspondence should be addressed; S. Prachayasittikul: E-mail: [email protected]; Tel. 662-664-1000 ext. 8209, Fax 662-259-2097; V. Prachayasittikul: E-mail: [email protected]; Tel. 662-418-0227, Fax 662-412-4110
Received: 1 April 2008; in revised form: 17 April 2008 / Accepted: 17 April 2008 / Published: 18 April 2008
Full Paper: Antimicrobial and Antioxidative Activities of Bioactive Constituents from Hydnophytum formicarum Jack.
Molecules 2008, 13, 904-921 (PDF format 201 K)


Feng Wang, Ruogu Peng and Yaowu Sha*
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 6 April 2008; in revised form: 17 April 2008 / Accepted: 18 April 2008 / Published: 19 April 2008
Full Paper: Selective Dendritic Fluorescent Sensors for Zn(II)
Molecules 2008, 13, 922-930 (PDF format 128 K)


Yun-Song Wang ^1,2, Hong-Pin He ², Jing-Hua Yang ¹, Ying-Tong Di ² and Xiao-Jiang Hao ^2,*
1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China; E-mails: [email protected] (Yun-Song Wang); [email protected] (Jing-Hua Yang)
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China; E-mails: [email protected] (Hong-Pin He), [email protected] (Ying-Tong Di)
* Author to whom correspondence may be addressed; E-mail: [email protected]; Tel: +86-871-5223263/ Fax: 86-871-5219684
Received: 19 January 2008; in revised form: 17 April 2008 / Accepted: 17 April 2008 / Published: 19 April 2008
Full Paper: New Monoterpenoid Coumarins from Clausena anisum-olens
Molecules 2008, 13, 931-937 (PDF format 100 K)


Kejun Cheng, Gaolin Liang and Changqi Hu *
Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, P. R. China; E-mails: [email protected] (for K. C.), [email protected] (for G. L.)
* Author to whom correspondence should be addressed; Tel: (+86)-21-54237564; Fax: (+86)-21-64183411; E-mail: [email protected]
Received: 13 March 2008; in revised form: 4 April 2008 / Accepted: 4 April 2008 / Published: 19 April 2008
Communication: Acid-catalyzed Epimerization of Kobophenol A to Carasinol B
Molecules 2008, 13, 938-942 (PDF format 173 K)
(This paper belongs to Special Issue on Heterocycles)


Nan Bai, Yaowu Sha* and Ge Meng
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 6 April 2008; in revised form: 17 April 2008 / Accepted: 17 April 2008 / Published: 21 April 2008
Communication: Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole
Molecules 2008, 13, 943-947 (PDF format 123 K)


Qingyong Tian, Daxin Shi and Yaowu Sha *
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 6 April 2008; in revised form: 17 April 2008 / Accepted: 17 April 2008 / Published: 21 April 2008
Full Paper: CuO and Ag₂O/CuO Catalyzed Oxidation of Aldehydes to the Corresponding Carboxylic Acids by Molecular Oxygen
Molecules 2008, 13, 948-957 (PDF format 686 K)


Rajiv Dahiya*, Anil Kumar and Rakesh Yadav
Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura-281001 (UP), India
*Author to whom correspondence should be addressed; Tel.: +91-9897417450; +91-565-6531680; E-mail: [email protected] or [email protected]
Received: 3 April 2008; in revised form: 18 April 2008 / Accepted: 19 April 2008 / Published: 24 April 2008
Full Paper: Synthesis and Biological Activity of Peptide Derivatives of Iodoquinazolinones/Nitroimidazoles
Molecules 2008, 13, 958-976 (PDF format 264 K)


Guillermo Negrón-Silva ^1,*, C. Xochitl Hernández-Reyes ¹, Deyanira Angeles-Beltrán ¹, Leticia Lomas-Romero ² and Eduardo González-Zamora ²
1 Departamento de Ciencias Básicas, UAM, Av. San Pablo No 180, C.P. 02200, México D. F., México; E-mails: C. X. Hernández-Reyes: [email protected]; D. Angeles-Beltrán: [email protected]
2 Departamento de Química, UAM, Av. San Pablo No 180, C.P. 02200, México D. F., México; Emails: L. Lomas-Romero: [email protected]; E. González Zamora: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 8 April 2008; in revised form: 24 April 2008 / Accepted: 24 April 2008 / Published: 26 April 2008
Full Paper: Microwave-Enhanced Sulphated Zirconia and SZ/MCM-41 Catalyzed Regioselective Synthesis of β-Amino Alcohols Under Solvent-Free Conditions
Molecules 2008, 13, 977-985 (PDF format 285 K)


George A. Kraus ^1,*, Insik Jeon ¹, Marit Nilsen-Hamilton ², Ahmed M. Awad ², Jayeeta Banerjee ² and Bahram Parvin ³
1 Iowa State University Department of Chemistry, Ames, IA 50011, USA; Tel. +1 515-294-7794; Fax: +1 515-294-0105
2 Iowa State University Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA; Tel. +1 515-9996; Fax: +1 515-294-0453
3 Lawrence Berkeley Laboratory Department of Cancer Biology, Berkeley, CA 94720, USA; Tel. +1 510-486-6203; Fax: +1 510-486-6363
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 21 March 2008; in revised form: 22 April 2008 / Accepted: 22 April 2008 / Published: 27 April 2008
Full Paper: Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Molecules 2008, 13, 986-994 (PDF format 286 K)


Manfred Braun ^1,*, Anahita Hessamian-Alinejad ¹, Boris Féaux de Lacroix ¹, Birte Hernandez Alvarez ² and Gunter Fischer ²
1 Department of Chemistry, University of Düsseldorf, Universitätstr. 1, D-40225 Düsseldorf, Germany
2 Max-Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D-06120 Halle, Germany
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 3 April 2008; in revised form: 22 April 2008 / Accepted: 23 April 2008 / Published: 29 April 2008
Full Paper: Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
Molecules 2008, 13, 995-1003 (PDF format 59 K)
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Julien Paolini *, Jean-Marie Desjobert, Alain Muselli and Jean Costa
Université de Corse, UMR-CNRS 6134, Laboratoire de Chimie des Produits Naturels, BP 52, 20250 Corti, France
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: +33 04 95 45 01 93
Received: 31 March 2008; in revised form: 28 April 2008 / Accepted: 28 April 2008 / Published: 29 April 2008
Full Paper: Spectral Data of Two New Asymmetric Sesquiterpene Alcohols: (14R)-β-Oplopenol and (14S)-β-Oplopenol
Molecules 2008, 13, 1004-1010 (PDF format 105 K)


Nada M. Abunada ^1,*, Hamdi M. Hassaneen ², Nadia G. Kandile ³ and Omar A. Miqdad ¹
1 Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine; E-mail: [email protected] (O. A. Miqdad)
2 Department of Chemistry, Faculty of Science, Cairo University, Egypt; E-mail: [email protected] (H. M. Hassaneen)
3 Department of Chemistry, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt; E-mail: [email protected] (N. G. Kandile)
*Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 8 April 2008; in revised form: 22 April 2008 / Accepted: 22 April 2008 / Published: 29 April 2008
Full Paper: Synthesis and Biological Activity of Some New Pyrazoline and Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of Nitrilimines with Some Dipolarophiles
Molecules 2008, 13, 1011-1024 (PDF format 161 K)

Editorial: Changes Coming to MDPI Journals: Digital Object Identifier (DOI) and Creative Commons Attribution License

Aleš Mráček ^1,*, Júlia Varhaníková ¹, Marián Lehocký ², Lenka Gřundělová ¹, Alena Pokopcová ¹ and Vladimír Velebný ³
1 Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Nad Stráněmi 4511, 76005 Zlín, Czech Republic; E-mails: [email protected]; [email protected]; [email protected]
2 Medical Materials Research Centre, Technology park, University Institute, Tomas Bata University in Zlín, Nad Ovcirnou III 3685, Zlín, 76001 Czech Republic; E-mail: [email protected]
3 CPN Ltd., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]; Fax: +420576035141; Tel: +420576035102
Received: 28 February 2008; in revised form: 17 April 2008 / Accepted: 30 April 2008 / Published: 1 May 2008
Article: The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity
Molecules 2008, 13, 1025-1034 (PDF format 489 K); DOI: 10.3390/molecules13051025
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Barbara Pavan ^1,*, Alessandro Dalpiaz ², Nunzia Ciliberti ², Carla Biondi ¹, Stefano Manfredini ² and Silvia Vertuani ²
1 University of Ferrara, Department of Biology, General Physiology Section, via L. Borsari 46, 44100, Ferrara, Italy
2 University of Ferrara, Department of Pharmaceutical Sciences, via Fossato di Mortara 19, 44100, Ferrara, Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +39-0532-455476; Fax: +39-0532-207143
Received: 1 February 2008; in revised form: 1 April 2008 / Accepted: 30 April 2008 / Published: 1 May 2008
Review: Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach
Molecules 2008, 13, 1035-1065 (PDF format 225 K); DOI: 10.3390/molecules13051035
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Elham S. Darwish
Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt; E-mail: [email protected]
Received: 3 April 2008; in revised form: 24 April 2008 / Accepted: 24 April 2008 / Published: 1 May 2008
Article: Facile Synthesis of Heterocycles via 2-Picolinium Bromide and Antimicrobial Activities of the Products
Molecules 2008, 13, 1066-1078 (PDF format 132 K); DOI: 10.3390/molecules13051066


Derek McPhee and Shu-Kun Lin
Molecular Diversity Preservation International (MDPI), Matthaeusstrasse 11, CH-4057 Basel, Switzerland; Fax: +41 61 302 8918; E-mails: [email protected]; [email protected]
Received: 1 May 2008 / Published: 2 May 2008
Editorial: Changes Coming to MDPI Journals: Digital Object Identifier (DOI) and Creative Commons Attribution License
Molecules 2008, 13, 1079-1080 (PDF format 21 K); DOI: 10.3390/molecules13051079


Marcel Holzer ¹, Sigrid Ziegler ¹, Beatrice Albrecht ¹, Bernd Kronenberger ¹, Artur Kaul ², Ralf Bartenschlager ², Lars Kattner ³, Christian D. Klein ¹ and Rolf W. Hartmann ^1,*
1 Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 151150, D-66041 Saarbrücken, Germany
2 Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, D-69120 Heidelberg, Germany
3 Endotherm GmbH, Science-Park II, D-66123 Saarbrücken, Germany
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 26 March 2008; in revised form: 2 May 2008 / Accepted: 7 May 2008 / Published: 7 May 2008
Article: Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization
Molecules 2008, 13, 1081-1110 (PDF format 183 K); DOI: 10.3390/molecules13051081


Jiabo Li and Yaowu Sha*
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 29 April 2008; in revised form: 5 May 2008 / Accepted: 6 May 2008 / Published: 8 May 2008
Communication: A Convenient Synthesis of Amino Acid Methyl Esters
Molecules 2008, 13, 1111-1119 (PDF format 145 K); DOI: 10.3390/molecules13051111


Isidro S. Marcos ^1,*, Almudena Conde ¹, Rosalina F. Moro ¹, Pilar Basabe ¹, David Díez ¹, Faustino Mollinedo ^2,3 and Julio G. Urones ¹
1 Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain
2 Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, Campus Miguel de Unamuno, E-37007 Salamanca, Spain
3 APOINTECH, Campus Miguel de Unamuno, E-37007 Salamanca, Spain
* Author to whom correspondence should be addressed; E-mail:[email protected]
Received: 28 April 2008; in revised form: 7 May 2008 / Accepted: 7 May 2008 / Published: 9 May 2008
Article: Synthesis of an ent-Halimanolide from ent-Halimic Acid
Molecules 2008, 13, 1120-1134 (PDF format 88 K); DOI: 10.3390/molecules13051120


Alper Aytekin * and Aynur Ozkul Acikgoz
Zonguldak Karaelmas University, Bartin Forestry Faculty, 74100 – Bartin, Turkey
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 4 April 2008; in revised form: 17 April 2008 / Accepted: 9 May 2008 / Published: 13 May 2008
Article: Hormone and Microorganism Treatments in the Cultivation of Saffron (Crocus Sativus L.) Plants
Molecules 2008, 13, 1135-1147 (PDF format 297 K); DOI: 10.3390/molecules13051135


Min Chen ^1,*, Zhihua Liao ², Xiumei Xu ^2,3, Yan Wen ², Min Sun ², Haoxiang Zhang ² and Wenhui Ma ⁴
1 School of Pharmacy, Three Gorges Reservoir Region Key Laboratory of Eco-environmental Science (Ministry of Education), Southwest University, Chongqing 400715, P.R. China
2 School of Life Sciences, Three Gorges Reservoir Region Key Laboratory of Eco-environmental Science (Ministry of Education), Southwest University, Chongqing 400715, P.R. China; E-mails: [email protected] (Liao); [email protected] (Xu); [email protected] (Wen); [email protected] (Sun); [email protected] (Zhang)
3 School of Life Sciences, Linyi Normal University, Linyi, Shandong Province, 276005, P.R. China
4 Department of Life Sciences, Hainan Normal University, Haikou, Hainan Province, 571158, P.R. China; E-mail: [email protected]
*Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: (+86) 2368251225; Fax: (+86) 68251225.
Received: 9 April 2008; / in revised form: 5 May 2008 / Accepted: 5 May 2008 / Published: 13 May 2008
Article: Neglschisandrins C-D: Two New Dibenzocyclooctadiene Lignans from Schisandra neglecta
Molecules 2008, 13, 1148-1155 (PDF format 207 K); DOI: 10.3390/molecules13051148


Marinella G. Sandros ^1,3, Chady B. Sarraf ^4,5 and Maryam Tabrizian ^1,2,3,*
1 Department of Biomedical Engineering, McGill University, 3775 University Street, Montreal, QC, Canada H3A2B4
2 Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada, H3A 2B2
3 Center for Biorecognition and Biosensors, McGill Institute for Advanced Materials, 3775 University Street, Montreal, QC, Canada H3A2B4
4 Department of Medical Education, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
5 St. Michael’s Medical Center, 111 Central Avenue, Newark, NJ 070102, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 5 February 2008; in revised form: 14 May 2008 / Accepted: 14 May 2008 / Published: 14 May2008
Review: Prodrugs in Cardiovascular Therapy
Molecules 2008, 13, 1156-1178 (PDF format 423 K); DOI: 10.3390/molecules13051156
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Yan-Hui Yang ¹, Qing-He Wang ¹, Han Nie ¹, Hong Chen ² and Mao-Sheng Cheng ^1,*
1 Key Lab of New Drug Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China; E-mails: [email protected]; [email protected], [email protected].
2 Staff Room of Pharmacognosy, Medical College of Chinese People’s Armed Police Force, Tianjin 300162, P. R. China; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 3 May 2008; in revised form: 19 May 2008 / Accepted: 19 May 2008 / Published: 20 May 2008
Article: Synthesis, Biological Evaluation, and Modeling of Dimeric PPI Analogues as Novel DNA Minor Groove Binders
Molecules 2008, 13, 1179-1188 (PDF format 285 K); DOI: 10.3390/molecules13051179


Guang-Yan Tang, Xue-Juan Li and Hong-Yu Zhang *
School of Life Sciences, Shandong University of Technology, Zibo 255049, P. R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 9 May 2008; in revised form: 22 May 2008 / Accepted: 22 May 2008 / Published: 23 May 2008
Communication: Antidiabetic Components Contained in Vegetables and Legumes
Molecules 2008, 13, 1189-1194 (PDF format 86 K); DOI: 10.3390/molecules13051189


Maria Iuliana Gruia ¹, Eliza Oprea ², Ion Gruia ³, Valentina Negoita ¹ and Ileana Cornelia Farcasanu ^2,*
1 Institute of Oncology Bucharest, 252 Fundeni, 022338, Bucharest, Romania
2 University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta, 030018, Bucharest, Romania
3 University of Bucharest, Faculty of Physics, MG-11 Magurele, 077125, Bucharest, Romania
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 9 April 2008; in revised form: 21 May 2008 / Accepted: 21 May 2008 / Published: 27 May 2008
Article: The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors
Molecules 2008, 13, 1195-1206 (PDF format 80 K); DOI: 10.3390/molecules13051195


Vincent Gloaguen ^1,*, Pierre Krausz ¹, Véronique Brudieux ^1,2, Brigitte Closs ², Yves Leroy ³ and Yann Guerardel ³
1 Laboratoire de Chimie des Substances Naturelles (UPRES-EA 1069), Université de Limoges, Faculté des Sciences et Techniques, 123 rue A. Thomas, 87060 Limoges, France
2 R&D Department, SILAB, ZI de la Nau, 19240 Saint-Viance, France
3 Unité de Glycobiologie Structurale, UMR-CNRS 8576, Université de Lille, F-59655, France
* Author to whom correspondance should be addressed; E-mail: [email protected]. Phone: +33 555457481.
Received: 13 March 2008; in revised form: 19 May 2008 / Accepted: 19 May 2008 / Published: 27 May 2008
Article: Structural Patterns of Rhamnogalacturonans Modulating Hsp-27 Expression in Cultured Human Keratinocytes
Molecules 2008, 13, 1207-1218 (PDF format 98 K); DOI: 10.3390/molecules13051207
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])

 

Simona De Marino ¹, Fulvio Gala ¹, Franco Zollo ¹, Sara Vitalini ², Gelsomina Fico ², Francesco Visioli ³ and Maria Iorizzi ^4,*
1 Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”,Via D. Montesano 49, I-80131 Napoli, Italy; E-mail: [email protected], [email protected], [email protected]
2 Dipartimento di Biologia, Università degli Studi di Milano, Via Celoria 26, I-20133 Milano, Italy; Email: [email protected], [email protected]
3 UMR7079,UPMC Univ Paris 06, Paris, France; E-mail: [email protected]
4 Dipartimento di Scienze e Tecnologie per l’Ambiente e il Territorio, Università degli Studi del Molise, Contrada Fonte Lappone, I-86090 Pesche (Isernia), Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +39 0874 404100; Fax: +39 0874 404123.
Received: 6 May 2008 / Accepted: 29 May 2008 / Published: 1 June 2008
Article: Identification of Minor Secondary Metabolites from the Latex of Croton lechleri (Muell-Arg) and Evaluation of Their Antioxidant Activity
Molecules 2008, 13, 1219-1229 (PDF format 126 K); DOI: 10.3390/molecules13061219


Francesco P. Ballistreri *, Ugo Chiacchio, Antonio Rescifina*, Gaetano Tomaselli and Rosa M. Toscano
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, Catania 95125, Italy; E-mails: [email protected]; [email protected]; [email protected]
* Authors to whom correspondence should be addressed; E-mails: [email protected] (Francesco Ballistreri) and [email protected] (Antonio Rescifina)
Received: 29 April 2008; in revised form: 12 May 2008 / Accepted: 15 May 2008 / Published: 1 June 2008
Article: Conversion of Oximes to Carbonyl Compounds by Triscetylpyridinium Tetrakis(oxodiperoxotungsto) Phosphate (PCWP)-mediated Oxidation with Hydrogen Peroxide
Molecules 2008, 13, 1230-1237 (PDF format 53 K); DOI: 10.3390/molecules13061230


Felix Adje ^1,3,4,5, Yves F. Lozano ^1,*, Emmanuelle Meudec ², Paul Lozano ¹, Augustin Adima ³, Georges Agbo N’zi ⁴ and Emile M. Gaydou ⁵
1 CIRAD, UMR GPEB Génie des Procédés – Eau, Bioproduits, TA 40/16, 73 avenue J.F. Breton, 34398 Montpellier cedex 5, France
2 INRA, UMR SPO Sciences pour l'Oenologie, Plateforme Polyphénols, 2 place Viala, 34060 Montpellier cedex 1, France
3 INP-HB Institut National Polytechnique Félix Houphouët-Boigny, Laboratoire de Procédés Industriels, de Synthèse et de l’Environnement (LAPISEN), Unité Chimie de l'Eau et des Substances Naturelles, BP 1313 Yamoussoukro, Ivory Coast
4 Université d'Abidjan-Cocody, UFR Biosciences, Laboratoire de Biochimie et Sciences des Aliments, 22 BP 582 Abidjan 22, Ivory Coast
5 UMR CNRS 6263, Equipe AD2M (Phytochimie), Institut des Sciences Moléculaires de Marseille, Université Paul Cézanne, Faculté des Sciences et Techniques de Saint-Jérôme, Avenue Escadrille Normandie Niémen, Case 461, Marseille cedex 20, France
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: +33-467614447; Fax: +33-467616537
Received: 5 May 2008; in revised form: 29 May 2008 / Accepted: 29 May 2008 / Published: 1 June 2008
Article: Anthocyanin Characterization of Pilot Plant Water Extracts of Delonix regia Flowers
Molecules 2008, 13, 1238-1245 (PDF format 176 K); DOI: 10.3390/molecules13061238


Grazia Cottone ¹, Rosina Noto ² and Gianfranco La Manna ^3,*
1 Dipartimento di Scienze Fisiche ed Astronomiche, Università di Palermo, Via Archirafi 36, I-90123 Palermo and CNISM, Italy; E-mail: [email protected]
2 IBF Sezione di Palermo, Via Ugo La Malfa 153, I-90146 Palermo, Italy; E-mail: [email protected]
3 Dipartimento di Chimica Fisica "F. Accascina", Università degli Studi di Palermo, Viale delle Scienze, I-90128 Palermo, Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel. +39 091 6459851; Fax: +39 091 590015
Received: 25 April 2008; in revised form: 26 May 2008 / Accepted: 28 May 2008 / Published: 3 June 2008
Article: Density Functional Theory Study of the Trans-Trans-Cis (TTC)→Trans-Trans-Trans (TTT) Isomerization of a Photochromic Spiropyran Merocyanine
Molecules 2008, 13, 1246-1252 (PDF format 178 K); DOI: 10.3390/molecules13061246
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Joel Campos De-Paula ^1,2, Ludmila Bomeny Bueno ³, Diana Negrão Cavalcanti ⁴, Yocie Yoneshigue-Valentin ⁵ and Valéria Laneuville Teixeira ^4,*
1 Departamento de Biologia Vegetal, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, 20550-013, Brazil; E-mail: [email protected]
2 Programa de Pós-Graduação em Ciências Biológicas (Botânica), Museu Nacional, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 20940-040, Brazil
3 Programa de Pós-Graduação em Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil; E-mail: [email protected]
4 Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense, CP 100. 644, Niterói, RJ, 24001-970, Brazil; E-mail: [email protected]
5 Departamento de Botânica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 30 April 2008; in revised form: 2 June 2008 / Accepted: 3 June 2008 / Published: 4 June 2008
Article: Diterpenes from the Brown Alga Dictyota crenulata
Molecules 2008, 13, 1253-1262 (PDF format 316 K); DOI: 10.3390/molecules13061253


Hossein Tajik ¹, Mehran Moradi ^1,*, Seyed Mehdi Razavi Rohani ¹, Amir Mehdi Erfani ² and Farnood Shokouhi Sabet Jalali ³
1 Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, 1177, Urmia, Iran
2 General Office of Veterinary, 45169-43374, Zanjan, Iran
3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, 1177, Urmia, Iran
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: +98- 441 2972512; Fax: +98-441 2771926
Received: 24 April 2008; in revised form: 8 May 2008 / Accepted: 9 May 2008 / Published: 6 June 2008
Article: Preparation of Chitosan from Brine Shrimp (Artemia urmiana) Cyst Shells and Effects of Different Chemical Processing Sequences on the Physicochemical and Functional Properties of the Product
Molecules 2008, 13, 1263-1274 (PDF format 147 K); DOI: 10.3390/molecules13061263
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Yan Qiu * and Xiu Min Wang
Department of Pharmacy, School of Medical, Xiamen University, Xiamen 361005, People’s Republic of China; E-mail: [email protected].
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel: (+86) 592-2188681; Fax: (+86) 592-2188676
Received: 23 May 2008; in revised form: 5 June 2008 / Accepted: 5 June 2008 / Published: 6 June 2008
Communication: A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
Molecules 2008, 13, 1275-1281 (PDF format 134 K); DOI: 10.3390/molecules13061275


Rabih O. Al-Kaysi ^1,*, Iluminada Gallardo ² and Gonzalo Guirado ^2,*
1 Department of Basic Sciences, King Saud Bin Abdulaziz University for Health Sciences-National
Guard Health Affairs. Building Mail Code 3124. Riyadh 11423. Kingdom of Saudi Arabia; Phone: (966)-5-61429528
2 Departament de Química, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain; Phone: (+) 00 34 93 581 48 82; Fax: (+) 00 34 93 581 29 20
* Authors to whom correspondence should be addressed; E-mails: [email protected], [email protected]
Received: 15 May 2008; in revised form: 6 June 2008 / Accepted: 6 June 2008 / Published: 9 June 2008
Review: Stable Spirocyclic Meisenheimer Complexes
Molecules 2008, 13, 1282-1302 (PDF format 168 K); DOI: 10.3390/molecules13061282
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Luis R. Domingo, Salvador Gil, Margarita Parra* and José Segura
Department of Organic Chemistry, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain; Fax +34(9)63543831; E-mails: [email protected]; [email protected]; [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 29 May 2008; in revoised form: 5 June 2008 / Accepted: 6 June 2008 / Published: 9 June 2008
Communication: Unusual Regioselectivity in the Opening of Epoxides by Carboxylic Acid Enediolates
Molecules 2008, 13, 1303-1311 (PDF format 140 K); DOI: 10.3390/molecules13061303


Anna Caruso ^1,2, Anne Sophie Voisin-Chiret ¹, Jean-Charles Lancelot ¹, Maria Stefania Sinicropi ², Antonio Garofalo ² and Sylvain Rault ^1,*
1 Université de Caen Basse-Normandie, U.F.R. des Sciences Pharmaceutiques, Centre d’Etudes et de Recherche sur le Médicament de Normandie, UPRES EA-4258 FR CNRS INC3M, 5, rue
Vaubénard, 14032 Caen Cedex, France
2 Università della Calabria, Dipartimento di Scienze Farmaceutiche, 87036 Arcavacata di Rende (CS), Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: +33 (0)2 31 93 64 58; Fax: +33 (0)2 31 93 11 88
Received: 3 June 2008; in revised form: 10 June 2008 / Accepted: 10 June 2008 / Published: 11 June 2008
Article: Efficient and Simple Synthesis of 6-Aryl-1,4-dimethyl-9H-carbazoles
Molecules 2008, 13, 1312-1320 (PDF format 64 K); DOI: 10.3390/molecules13061312


Joana S. Amaral ^1,2,*, Patrícia Valentão ¹, Paula B. Andrade ¹, Rui C. Martins ³ and Rosa M. Seabra ¹
1 REQUIMTE, Serviço de Farmacognosia, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4099-030 Porto, Portugal; E-mails: [email protected], [email protected],
[email protected]
2 Escola Superior de Tecnologia e de Gestão, Instituto Politécnico de Bragança, Quinta de Sta. Apolónia, Apartado 134, 5301-857 Bragança, Portugal
3 Centre for Biological Engineering, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 7 May 2008; in revised form: 7 June 2008 / Accepted: 8 June 2008 / Published: 12 June 2008
Article: Do Cultivar, Geographical Location and Crop Season Influence Phenolic Profile of Walnut Leaves?
Molecules 2008, 13, 1321-1332 (PDF format 147 K); DOI: 10.3390/molecules13061321


Yu Qiao, Bi Jun Xie, Yan Zhang, Yun Zhang, Gang Fan, Xiao Lin Yao and Si Yi Pan *
College of Food Science and Technologhy, Huazhong Agricultural University, Shizhishan Street No. 1, Wuhan, Hubei, 430070, P. R. China
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 20 April 2008; in revised form: 19 May 2008 / Accepted: 19 May 2008 / Published: 12 June 2008
Article: Characterization of Aroma Active Compounds in Fruit Juice and Peel Oil of Jinchen Sweet Orange Fruit (Citrus sinensis (L.) Osbeck) by GC-MS and GC-O
Molecules 2008, 13, 1333-1344 (PDF format 241 K); DOI: 10.3390/molecules13061333


Steven C. Farmer* and Seth H. Berg
Department of Chemistry, Sonoma State University, 1801 East Cotati Avenue, Rohnert Park, California 94928, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: +1-(707) 664-3728
Received: 1 June 2008; in revised form: 10 June 2008 / Accepted: 10 June 2008 / Publshed: 12 June 2008
Article: Ring Contracting Sulfur Extrusion from Oxidized Phenothiazine Ring Systems
Molecules 2008, 13, 1345-1352 (PDF format 92 K); DOI: 10.3390/molecules13061345


Zu-Ming Liu, Qiong Chen, Chao-Nan Chen, Hai-Yang Tu * and Guang-Fu Yang
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China; http://klpcb.ccnu.edu.cn/
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 6 May 2008; in revised form: 26 May 2008 / Accepted: 26 May 2008 / Published: 13 June 2008
Article: Syntheses of Diheterocyclic Compounds Based on 2-Thioacetohydrazide-5,7-dimethyl-1,2,4-triazolo[1,5-a]-pyrimidine
Molecules 2008, 13, 1353-1360 (PDF format 92 K); DOI: 10.3390/molecules13061353


Shou-Fang Wu ¹, Pei-Wen Hsieh ^1,2, Chin-Chung Wu ^1,2, Chia-Lin Lee ¹, Shu-Li Chen ¹, Chi-Yu Lu ^2,3, Tian-Shung Wu ⁴, Fang-Rong Chang ^1,2,* and Yang-Chang Wu ^1,2,*
1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-mails: [email protected] (S.F. Wu), [email protected] (P.W. Hsieh), [email protected] (Y.C. Wu)
2 Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3 Department of Biochemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-mail:[email protected] (C.Y. Lu)
4 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan; E-mail: [email protected]
* Authors to whom correspondence should be addressed. TEL: +886-7-312-1101 ext. 2197. Fax: +886-7-311-4773. E-mails: [email protected] or [email protected] (F.R. Chang)
Received: 9 May 2008; in revised form: 3 June 2008 / Accepted: 3 June 2008 / Published: 16 June 2008
Article: Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida
Molecules 2008, 13, 1361-1371 (PDF format 295 K); DOI: 10.3390/molecules13061361


Tim S. Bugni, Mary Kay Harper, Malcolm W.B. McCulloch, Jason Reppart and Chris M. Ireland *
Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed; [email protected] Tel.: +1 (801) 581-8305; Fax: +1 (801) 585-6208
Received: 3 June 2008; in revised form: 18 June 2008 / Accepted: 18 June 2008 / Published: 19 June 2008
Article: Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
Molecules 2008, 13, 1372-1383 (PDF format 284 K); DOI: 10.3390/molecules13061372
(This paper belongs to Special Issue on Natural Product Pre-fractionation. Guest Editor: Dr. John A. Beutler)


Giuseppina Tommonaro*, Annarita Poli, Salvatore De Rosa and Barbara Nicolaus
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche (C.N.R.), Via Campi Flegrei, 34 80078 Pozzuoli (Napoli), Italy; E-mails: [email protected] (A. Poli);
[email protected] (S. De Rosa); [email protected] (B. Nicolaus)
* Author to whom correspondence should be addressed; E-mail:
[email protected]; Phone: +39-81-8675104; Fax: +39-81-8041770
Received: 30 May 2008; in revised form: 17 June 2008 / Accepted: 17 June 2008 / Published: 19 June 2008
Review: Tomato Derived Polysaccharides for Biotechnological Application: Chemical and Biological Approaches
Molecules 2008, 13, 1384-1398 (PDF format 412 K); DOI: 10.3390/molecules13061384
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Xiu Min Wang ¹, Chun Peng Wan ^1,2, Shou Ran Zhou ² and Yan Qiu ^1,*
1 Department of Pharmacy, School of Medical, Xiamen University, Xiamen 361005, People′s Republic of China; E-mail: [email protected].
2 Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, People′s Republic of China; E-mail: [email protected] (Wan). E-mail: [email protected] (Zhou).
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel: (+86) 592-2188681; Fax: (+86) 592-2188676
Received: 4 June 2008; in revised form:17 June 2008 / Accepted: 17 June 2008 / Published: 19 June 2008
Communication: Two New Flavonol Glycosides from Sarcopyramis bodinieri var. delicate
Molecules 2008, 13, 1399-1405 (PDF format 152 K); DOI: 10.3390/molecules13061399


Melissa M. Wagenaar
Natural Products Discovery Research, Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA; E-mail: [email protected]
Received: 30 May 2008 / Accepted: 16 June 2008 / Published: 20 June 2008
Article: Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth
Molecules 2008, 13, 1406-1426 (PDF format 487 K); DOI: 10.3390/molecules13061406
(This paper belongs to Special Issue on Natural Product Pre-fractionation. Guest Editor: Dr. John A. Beutler)


Jin-Ling Lv ¹, Rui Wang ¹, Dan Liu ¹, Gang Guo ¹, Yong-Kui Jing ² and Lin-Xiang Zhao ^1,*
1 Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; E-mails: [email protected] (Guo)
2 Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: (+86)24-23986420; Fax: (+86)24-23986420.
Received: 5 June 2008; in revised form: 22 June 2008 / Accepted: 23 June 2008 / Published: 24 June 2008
Article: Design, Synthesis, and Antitumor Activities of Some Novel Substituted 1,2,3-Benzotriazines
Molecules 2008, 13, 1427-1440 (PDF format 487 K); DOI: 10.3390/molecules13061427

 

Yasuhiro Tsume ¹, Balvinder S. Vig ², Jing Sun ³, Christopher P. Landowski ⁴, John M. Hilfinger ⁵, Chandrasekharan Ramachandran ¹ and Gordon L. Amidon 1,*
1 Department of Pharmaceutical Science, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA; E-mails: [email protected]; [email protected]
2 Pharmaceutical Research Institute, Bristol-Myers Squibb Company, New Brunswick, NJ 08502; E-mail: [email protected]
3 Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA; Email: [email protected]
4 Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012 Bern, Switzerland; E-mail: [email protected]
5 TSRL, Inc. Ann Arbor, Michigan 48108, USA; Email: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: +1-734-764-2440; Fax: +1-734-763-6423.
Received: 12 June 2008 / Accepted: 27 June 2008 / Published: 28 June 2008
Article: Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters
Molecules 2008, 13, 1441-1454 (PDF format 132 K); DOI: 10.3390/molecules13071441
(This paper belongs to Special Issue on 5-Fluorouracil. Guest Editor: Dr. Francesco Puoci)


Neda Mimica-Dukic ^1,*, Natasa Simin ¹, Jelena Cvejic ², Emilija Jovin ¹, Dejan Orcic ¹ and Biljana Bozin ²
1 Department of Chemistry, Faculty of Sciences, Trg D. Obradovica 3, University of Novi Sad, 21000 Novi Sad, Serbia. E-mails: [email protected], [email protected]
2 Department of Pharmacy, Faculty of Medicine, Hajduk Veljkova 3, University of Novi Sad, 21000 Novi Sad, Serbia. E-mails: [email protected], [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: +38121- 4852757; Fax: +38121-454650
Received: 12 June 2008; in revised form: 01 July 2008 / Accepted: 15 July 2008 / Published: 15 July 2008
Article: Phenolic Compounds in Field Horsetail (Equisetum arvense L.) as Natural Antioxidants
Molecules 2008, 13, 1455-1464 (PDF format 292 K); DOI: 10.3390/molecules13071455
(This paper belongs to Special Issue on Phenolics and Polyphenolics. Guest Editors: Dr. José Alberto Pereira and Dr. Paula Andrade)
 

Ernesto Fattorusso, Adriana Romano, Fernando Scala and Orazio Taglialatela-Scafati *
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy.; E-mails: [email protected]; [email protected]; [email protected]
* Author to whom correspondence should be addressed. Tel. +39-081678509; E-mail: [email protected]
Received: 25 June 2008 / Accepted: 16 July 2008 / Published: 17 July 2008
Article: Simplexidine, a 4-Alkylpyridinium Alkaloid from the Caribbean Sponge Plakortis simplex
Molecules 2008, 13, 1465-1471 (PDF format 206 K); DOI: 10.3390/molecules13071465
(This paper belongs to Special Issue on Alkaloids. Guest Editors: Prof. Dr. Patricia Valentao and Prof. Dr. Mariana Sottomayor)


Yu Sha, Mao-Cai Yan, Jiao Liu, Yang Liu and Mao-Sheng Cheng *
Key Lab of New Drug Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
E-mails: [email protected] (Y. S.); [email protected] (M.-C. Y.); [email protected] (Y. L.); [email protected] (Y. L.)
* Author to whom correspondence should be addressed: E-Mail: [email protected]
Received: 16 June 2008; in revised form: 18 July 2008 / Accepted: 18 July 2008 / Published: 22 July 2008
Article: Facile Synthesis of Oleanolic Acid Monoglycosides and Diglycosides
Molecules 2008, 13, 1472-1486 (PDF format 301 K); DOI: 10.3390/molecules13071472
 

Gang Guo ¹, Gang Li ¹, Dan Liu ¹, Qian-Jiao Yang ¹, Yu Liu ¹, Yong-Kui Jing ² and Lin-Xiang Zhao ^1,*
1 Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China; E-mails: [email protected](Guo); [email protected] (Li); [email protected](Liu); [email protected] (Yang); [email protected] (Liu)
2 Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: (+86)24-23986420; Fax: (+86)24-23986420.
Received: 20 June 2008; in revised form: 15 July 2008 / Accepted: 15 July 2008 / Published: 23 July 2008
Article: Synthesis and Antiproliferative Activities of 5-Azacytidine Analogues in Human Leukemia Cells
Molecules 2008, 13, 1487-1500 (PDF format 279 K); DOI: 10.3390/molecules13071487


Nada M. Abunada ^1,*, Hamdi M. Hassaneen ², Nadia G. Kandile ³ and Omar A. Miqdad ¹
1 Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine; E-mail: [email protected] (O. A. Miqdad)
2 Department of Chemistry, Faculty of Science, Cairo University, Egypt; E-mail: [email protected] (H. M. Hassaneen)
3 Department of Chemistry, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt; E-mail: [email protected] (N. G. Kandile)
*Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 4 May 2008; in revised form: 21 July 2008 / Accepted: 22 July 2008 / Published: 29 July 2008
Article: Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
Molecules 2008, 13, 1501-1517 (PDF format 335 K); DOI: 10.3390/molecules13071501
 

Alexandra CH F Sawaya ^1,2,*, Ilka Nacif Abreu ^3,4, Nathalia Luiza Andreazza ³, Marcos N. Eberlin ¹ and Paulo Mazzafera ³
1 ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas - UNICAMP, Campinas, SP, Brazil
2 Bandeirante University of São Paulo, UNIBAN, São Paulo, SP, Brazil
3 Department of Plant Physiology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, SP, Brazil
4 Umeå Plant Science Centre – Umeå – Sweden
* Author to whom correspondence should be addressed; e-mail: [email protected]; UNIBAN,Rua Maria Cândida 1813, Vila Guilheme, São Paulo, CEP 02071-013, SP, Brazil, Phone: +55-11-2967-9147; Fax: +55-11-4412-5871.
Received: 28 May 2008; in revised form: 22 June 2008 / Accepted: 18 July 2008 / Published: 30 July 2008
Article: HPLC-ESI-MS/MS of Imidazole Alkaloids in Pilocarpus microphyllus
Molecules 2008, 13, 1518-1529 (PDF format 323 K); DOI: 10.3390/molecules13071518
(This paper belongs to Special Issue on Alkaloids. Guest Editors: Prof. Dr. Patricia Valentao and Prof. Dr. Mariana Sottomayor) 

Xiang Li ^1,† , Zhi Liu ², Xin-feng Zhang ³, Li-juan Wang ¹, Yi-nan Zheng ¹, Chang-chun Yuan ² and Guang-zhi Sun ^2,*
1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, P.R. China; E-mails: [email protected]; [email protected]; [email protected]
2 Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, P.R. China; E-mails: [email protected]; [email protected]
3 College of Forestry and Biotechnology, Zhejiang Forestry University, Hangzhou, 311300, P.R. China; E-mail: [email protected]
† Present address: Agriculture and Agri-Food Canada, Saskatoon Research Center, 107 Science Place, Saskatoon, SK, S7N_0X2, Canada.
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +86-431-8451-0949, Fax: +86-431-8451-0409
Received: 2 July 2008; in revised form: 31July 2008 / Accepted: 31 July 2008 / Published: 3 August 2008
Article: Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana
Molecules 2008, 13, 1530-1537 (PDF format 195 K); DOI: 10.3390/molecules13081530

Wei-Ting Hung ¹, Shwu-Huey Wang ², Chung-Hsuan Chen ¹ and Wen-Bin Yang ^1,*
1 Genomics Research Center, Academia Sinica, No. 128, Academia Road Section 2, Nan-Kang, Taipei 11529, Taiwan
2 Instrument Center, Taipei Medical University, Taipei 11031, Taiwan
* Author to whom correspondence should be addressed. Tel.: +886-2-27899930 ext.339; Fax: +886-2-27899931; E-mail: [email protected]
Received: 26 May 2008; in revised form 21 June 2008 / Accepted: 25 July 2008 / Published: 3 August 2008
Article: Structure Determination of β-Glucans from Ganoderma lucidum with Matrix-assisted Laser Desorption/ionization (MALDI) Mass Spectrometry
Molecules 2008, 13, 1538-1550 (PDF format 482 K); DOI: 10.3390/molecules13081538
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Ning Zhang ¹, Ying Yin ², Sheng-Jie Xu ² and Wei-Shan Chen ^1,*
1 Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, 310009, P.R. China; E-mail: [email protected]
2 Institute of Clinical Research, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, #3 East Qingchun Road, Hangzhou, 310016, P.R. China; E-mails: [email protected], [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 18 June 2008; in revised form: 1 July 2008 / Accepted: 15 July 2008 / Published: 5 August 2008
Review: 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
Molecules 2008, 13, 1551-1569 (PDF format 214 K); DOI: 10.3390/molecules13081551
(This paper belongs to Special Issue on 5-Fluorouracil. Guest Editor: Dr. Francesco Puoci)


Jerzy Kossakowski ¹, Anna Bielenica ¹, Barbara Mirosław ², Anna E. Kozioł ², Izabela Dybała ² and Marta Struga ^1,*
1 Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland. Tel./Fax. +48(22)6280679.
2 Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 14 May 2008; in revised form: 19 June 2008 / Accepted: 25 July 2008 / Published: 6 August 2008
Article: 4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents
Molecules 2008, 13, 1570-1583 (PDF format 293 K); DOI: 10.3390/molecules13081570


Sabira Begum*, Syed Nawazish Ali, Farhat, Syed Imran Hassan and Bina S. Siddiqui
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan; E-mails: [email protected] (Syed Nawazish Ali); [email protected] (Farhat); [email protected] (Syed Imran Hassan); [email protected] (Bina S. Siddiqui)
* Author to whom correspondence should be addressed; E-mail: [email protected], [email protected]; Tel.: +92-21-4824901; Fax: +92-21-4819018/4819019
Received: 6 May 2008; in revised form: 24 June 2008 / Accepted: 23 July 2008 / Published: 6 August 2008
Article: A Simple, Rapid and Mild One Pot Synthesis of Benzene Ring Acylated and Demethylated Analogues of Harmine under Solvent-free Conditions
Molecules 2008, 13, 1584-1598 (PDF format 217 K); DOI: 10.3390/molecules13081584
(This paper belongs to Special Issue on Alkaloids. Guest Editors: Prof. Dr. Patricia Valentao and Prof. Dr. Mariana Sottomayor)


Josias H. Hamman
Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa; E-mail: [email protected]; Tel.: +27 12 382 6397; Fax: + 27 12 382 6243
Received: 28 May 2008 / Accepted: 25 July 2008 / Published: 8 August 2008
Review: Composition and Applications of Aloe vera Leaf Gel
Molecules 2008, 13, 1599-1616 (PDF format 227 K); DOI: 10.3390/molecules13081599
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Sorana D. Bolboacă ^1,2,*, Elena M. Pică ², Claudia V. Cimpoiu ³ and Lorentz Jäntschi ²
1 “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Medical Informatics and Biostatistics, 6 Louis Pasteur, 400349 Cluj-Napoca, Romania.
2 Technical University of Cluj-Napoca, 103-105 Muncii Bvd, 400641 Cluj-Napoca, Romania; E-mails: [email protected], [email protected].
3 “Babeş-Bolyai” University, Department of Analytical Chemistry, 11 Arany Janos, 400028 Cluj-Napoca, Romania; E-mail: [email protected].
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +4-0264-431697; Fax: +4-0264-593847.
Received: 23 May 2008; in revised form: 7 August 2008 / Accepted: 7 August 2008 / Published: 11 August 2008
Article: Statistical Assessment of Solvent Mixture Models Used for Separation of Biological Active Compounds
Molecules 2008, 13, 1617-1639 (PDF format 234 K); DOI: 10.3390/molecules13081617


M. Isabel García-Moreno ^1,*, Juan M. Benito ^2,*, Carmen Ortiz Mellet ¹ and José M. García Fernández ²
1 Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Profesor García González 1, 41012 Sevilla, Spain; E-mail: [email protected]
2 Instituto de Investigaciones Químicas, CSIC – Universidad de Sevilla, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain; E-mail: [email protected]
* Author to whom correspondence should be addressed: E-mail: [email protected], [email protected].
Received: 20 June 2008; in revised form 22 July 2008 / Accepted: 28 July 2008 / Published: 12 August 2008
Review: Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
Molecules 2008, 13, 1640-1670 (PDF format 508 K); DOI: 10.3390/molecules13081640
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Bo Li*, Fei Lu, Xinjun Wei and Ruixiang Zhao
School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, Henan, P.R. China; E-mails: [email protected] (Fei Lu), [email protected] (Xinjun Wei), [email protected] (Ruixiang Zhao)
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 27 May 2008; in revised form: 23 June 2008 / Accepted: 30 July 2008 / Published: 12 August 2008
Review: Fucoidan: Structure and Bioactivity
Molecules 2008, 13, 1671-1695 (PDF format 297 K); DOI: 10.3390/molecules13081671
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Kai-jin Wang ¹, Ning Li ^1,* and Hu Wang ²
1 College of Life Sciences, Anhui University, Hefei 230039, P. R. China; E-mail: [email protected] (Kai-jin Wang)
2 Modern Experiment Technology Center, Anhui University, Hefei 230039, P. R. China; E-mail: [email protected] (Hu Wang)
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: +86-551-5107341; Fax: +86-551-5107354.
Received: 13 June 2008; in revised form: 1 August 2008 / Accepted: 6 August 2008 / Published: 13 August 2008
Article: New Acetylenic Norlignan Compounds from Rhizomes of Curculigo crassifolia
Molecules 2008, 13, 1696-1701 (PDF format 191 K); DOI: 10.3390/molecules13081696


Hanen Marzouki ¹, Alessandra Piras ², Bruno Marongiu ^2,*, Antonella Rosa ³ and M. Assunta Dessì ³
1 Laboratoire de Botanique et de Biologie végétale, Université de Tunis, Tunisia; E-mail: [email protected]
2 Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy; E-mail: [email protected]
3 Dipartimento di Biologia Sperimentale, Sezione di Patologia Sperimentale, Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy; E-mail: [email protected]; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +39 070 6754412; Fax: + 39 070 6754388.
Received: 26 June 2008; in revised form: 28 July 2008 / Accepted: 5 August 2008 / Published: 13 August 2008
Article: Extraction and Separation of Volatile and Fixed Oils from Berries of Laurus nobilis L. by Supercritical CO₂
Molecules 2008, 13, 1702-1711 (PDF format 173 K); DOI: 10.3390/molecules13081702


Lirong Sun ¹, Jian Yan ^1,2, Yin Nian ^1,2, Lin Zhou ¹, Hongjie Zhang ³ and Minghua Qiu ^1,2,*
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, 650204, P. R. China
2 Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China
3 Program for Collaborative Research in the Pharmaceutical Sciences, (m/c877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood St., Chicago, IL 60612, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]; Fax: (+86)-871-5223255.
Received: 17 May 2008; in revised form: 17 July 2008 / Accepted: 18 July 2008 / Published: 13 August 2008
Article: New Triterpene Diglycosides from the Rhizome of Cimifuga foetida
Molecules 2008, 13, 1712-1721 (PDF format 269 K); DOI: 10.3390/molecules13081712


Javier Palazón ^1,*, Arturo Navarro-Ocaña ², Liliana Hernandez-Vazquez ¹ and Mohammad Hossein Mirjalili ³
1 Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Avda Diagonal 643, E-08028, Barcelona, Spain; E-mail: [email protected]
2 Departamento de Alimentos y Biotecnologia, Facultad de Química, Universidad Nacional Autónoma de México, México DF, México; E-mail: [email protected]
3 Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 3 June 2008; in revised form: 12 August 2008 / Accepted: 14 August 2008 / Published: 18 August 2008
Review: Application of Metabolic Engineering to the Production of Scopolamine
Molecules 2008, 13, 1722-1742 (PDF format 1422 K); DOI: 10.3390/molecules13081722
(This paper belongs to Special Issue on Alkaloids. Guest Editors: Prof. Dr. Patricia Valentao and Prof. Dr. Mariana Sottomayor)


Axel G. Griesbeck ^1,*, Lars-Oliver Höinck ¹, Johann Lex ¹, Jörg Neudörfl ¹, Dirk Blunk ^1,* and Tamer T. El-Idreesy ²
1 Department of Chemistry, Institute of Organic Chemistry, Greinstr. 4, 50939 Köln, Germany; E-mail: [email protected]
2 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt; E-mail: [email protected]
* Authors to whom correspondence should be addressed; E-mails: [email protected]; [email protected].
Received: 28 July 2008; in revised form: 15 August 2008 / Accepted: 18 August 2008 / Published: 19 August 2008
Article: 1,2,5,10,11,14-Hexaoxadispiro[5.2.5.2]hexadecanes: Novel Spirofused Bis-Trioxane Peroxides
Molecules 2008, 13, 1743-1758 (PDF format 760 K); DOI: 10.3390/molecules13081743
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Ricardo M. Camelo ¹, Fernanda S. G. Kehdy ³, Carlos E. Salas ^2,* and Miriam T. P. Lopes ¹
1 Department of Pharmacology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270-901, Brazil
2 Departamento Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal Minas Gerais, Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil
3 Department of General Biology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270-901, Brazil
* Author to whom correspondence should be addressed. E-mail: [email protected]; Phone/Fax: +55-31-3409-2646.
Received: 17 June 2008; in revised form: 13 August 2008 / Accepted: 14 August 2008 / Published: 21 August 2008
Article: Amifostine Protection Against Mitomycin-induced Chromosomal Breakage in Fanconi Anaemia Lymphocytes
Molecules 2008, 13, 1759-1772 (PDF format 222 K); DOI: 10.3390/molecules13081759


Naozumi Teramoto ^1,*, Navzer D. Sachinvala ^{2, †} and Mitsuhiro Shibata ¹
1 Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan; E-mail: [email protected]
2 Retired, Southern Regional Research Center, USDA-ARS, New Orleans, LA, USA; Home: 2261 Brighton Place, Harvey, LA 70058; E-mail: [email protected]
†Dedicated to Professor George Christensen, Department of Psychology, Winona State University, Winona, MN, USA.
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 13 July 2008 / Accepted: 11 August 2008 / Published: 21 August 2008
Review: Trehalose and Trehalose-based Polymers for Environmentally Benign, Biocompatible and Bioactive Materials
Molecules 2008, 13, 1773-1816 (PDF format 1743 K); DOI: 10.3390/molecules13081773
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Yu Sha ¹, Lei Zhang ¹, Gui-Jie Du ², Jian Ren ¹ and Mao-Sheng Cheng ^1,*
1 Key Lab of New Drug Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China; E-mails: [email protected]; [email protected]; [email protected]
2 Jinzhou Jiutai Pharmaceutical Co. Ltd, Jinzhou 121012, P.R. China; E-mail: [email protected]
* Author to whom correspondence should be addressed: E-Mail: [email protected].
Received: 5 June 2008; in revised form: 8 August 2008 / Accepted: 12 August 2008 / Published: 22 August 2008
Communication: Synthesis of RP 48497, an Impurity of Eszopiclone
Molecules 2008, 13, 1817-1821 (PDF format 162 K); DOI: 10.3390/molecules13081817


Xu-qiong Xiong, Dong-mei Zhao, Peng-fei Bu, Yang Liu, Jin-hong Ren, Jian Wang, and Mao-sheng Cheng *
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of  Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China, 110016; E-mails: [email protected] (Xu-qiong Xiong), [email protected] (Dong-mei Zhao), [email protected] (Peng-fei Bu), [email protected] (Yang Liu), [email protected] (Jin-hong Ren), [email protected] (Jian Wang)
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 29 July 2008; in revised form: 7 August 2008 / Accepted: 7 August 2008 / Published: 22 August 2008
Article: CoMFA, CoMSIA and Eigenvalue Analysis on  Dibenzodioxepinone and Dibenzodioxocinone Derivatives as Cholesteryl Ester Transfer Protein Inhibitors
Molecules 2008, 13, 1822-1839 (PDF format 1424 K); DOI: 10.3390/molecules13081822


Takashi Yamanoi *, Yoshiki Oda, Hitomi Muraishi and Sho Matsuda
The Noguchi Institute, 1-8-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan; E-mails: [email protected] (Yoshiki Oda), [email protected] (Hitomi Muraishi), [email protected] (Sho Matsuda)
* Author to whom correspondence should be addressed. E-mail: [email protected]; Fax: (+81) 3 5944 3213.
Received: 18 July 2008; in revised form: 12 August 2008 / Accepted: 19 August 2008 / Published: 22 August 2008
Article: Synthesis of a Novel D-Glucose-Conjugated 15-Crown-5 Ether with a Spiro Ketal Structure
Molecules 2008, 13, 1840-1845 (PDF format 203 K); DOI: 10.3390/molecules13081840
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Felikss Mutulis ^1,2,*, Adolf Gogoll ³, Ilze Mutule ^1,2, Sviatlana Yahorava ¹, Aleh Yahorau ¹, Edvards Liepinsh ² and Jarl E.S. Wikberg ¹
1 Department of Pharmaceutical Biosciences, Division of Pharmaceutical Pharmacology, Uppsala Biomedical center, Uppsala University, S-751 24, Uppsala, Sweden; E-mails: [email protected]; [email protected]; [email protected]
2 Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia; E-mail: [email protected]; [email protected]
3 Department of Biochemistry and Organic Chemistry, Box 576, Uppsala University, S-751 23, Uppsala, Sweden; E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected].
Received: 10 June 2008; in revised form: 18 August 2008 / Accepted: 19 August 2008 / Published: 26 August 2008
Article: Oligomerization of Indole Derivatives with Incorporation of Thiols
Molecules 2008, 13, 1846-1863 (PDF format 420 K); DOI: 10.3390/molecules13081846


Luiz Cláudio Almeida Barbosa ^1,*, Ulisses Alves Pereira ¹, Ana Paula Martinazzo ^2,3, Célia Regina Álvares Maltha ¹, Róbson Ricardo Teixeira ¹ and Evandro de Castro Melo ³
1 Department of Chemistry, Federal University of Viçosa, 36570-000, Viçosa, Minas Gerais, Brazil; E-mails: [email protected] (U.A.P.); [email protected] (C.R.A.M.), [email protected] (R.R.T.)
2 Department of Agricultural Engineering, Fluminense Federal University, Volta Redonda, Rio de Janeiro, Brazil; E-mail: [email protected] (A.P.M.)
3 Department of Agricultural Engineering, Federal University of Viçosa, 36570-000, Viçosa, Minas Gerais, Brazil; E-mail: [email protected] (E.C.M.)
* Author to whom correspondence should be addressed. E-mail: [email protected].
Received: 11 July 2008 ; in revised form: 21 August 2008 / Accepted: 22 August 2008 / Published: 27 August 2008
Article: Evaluation of the Chemical Composition of Brazilian Commercial Cymbopogon citratus (D.C.) Stapf Samples
Molecules 2008, 13, 1864-1874 (PDF format 219 K); DOI: 10.3390/molecules13081864


László F. Szabó
Department of Organic Chemistry, Semmelweis University, Hőgyes utca 7, H-1092 Budapest, Hungary; E-mail: [email protected]
Received: 5 August 2008; in revised form: 24 August 2008 / Accepted: 26 August 2008 / Published: 27 August 2008
Review: Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine
Molecules 2008, 13, 1875-1896 (PDF format 414 K); DOI: 10.3390/molecules13081875
(This paper belongs to Special Issue on Alkaloids. Guest Editors: Prof. Dr. Patricia Valentao and Prof. Dr. Mariana Sottomayor)


Georgios V. Koukourakis ^1,*, Vassilios Kouloulias ¹, Michael J. Koukourakis ², Georgios A. Zacharias ³, Haralabos Zabatis ⁴ and John Kouvaris ⁵
1 Attikon University Hospital of Athens, 2nd Radiology Department, Radiation Therapy Unit, Medical School of Athens, Greece; Emails: [email protected] (Koukourakis); [email protected] (Kouloulias)
2 University Hospital of Thrace, Radiation Therapy Unit, Alexandroupolis, Greece; Email: [email protected]
3 Policlinic of Athens, Section of Pathology, Athens Greece. Email: [email protected]
4 Saint Savvas Anticancer Institute of Athens, 1st Radiation Therapy Unit Athens Greece; Email: [email protected]
5 Aretaieion University Hospital, 1st Radiology Department, Radiation Therapy Unit, Medical School of Athens, Greece; Email: [email protected]
* Author to whom correspondence should be addressed. Email: [email protected].
Received: 30 May 2008; in revised form: 15 August 2008 / Accepted: 25 August 2008 / Published: 27 August 2008
Review: Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review
Molecules 2008, 13, 1897-1922 (PDF format 289 K); DOI: 10.3390/molecules13081897
(This paper belongs to Special Issue on 5-Fluorouracil. Guest Editor: Dr. Francesco Puoci)


Lin-chun Fu ¹, Xin-an Huang ^1,*, Zhen-yuan Lai ¹, Ying-jie Hu ¹, Hong-jiao Liu ² and Xiao-ling Cai ^3,*
1 Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, P.R. China; E-mails: [email protected] (Fu), [email protected] (Lai), [email protected] (Hu)
2 Department of Traditional Chinese Medicine, Guangzhou Women and Children Medical Center, Guangzhou 510120, P.R. China; E-mail: [email protected]
3 School of Chemistry & Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China
* Authors to whom correspondence should be addressed. E-mails: [email protected] (Huang), [email protected] (Cai); Faxes: +86-20-8637-3516 (Huang), +86- 20-8411-2245 (Cai)
Received: 28 July 2008; in revised form: 11 August 2008 / Accepted: 11 August 2008 / Published: 28 August 2008
Communication: A New 3-Benzylchroman Derivative from Sappan Lignum (Caesalpinia sappan)
Molecules 2008, 13, 1923-1930 (PDF format 264 K); DOI: 10.3390/molecules13081923


Yu-Lan Li ^1,2, Jun Li ², Nai-Li Wang ^1,* and Xin-Sheng Yao ^1,*
1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, P.R. China; E-mail: [email protected] (Yu-Lan Li)
2 Shenzhen Institute for Drug Control, 1024, Beihuan Road, Futian District, Shenzhen, Guangdong 518029, P.R. China; E-mail: [email protected] (Jun Li)
* Authors to whom correspondence should be addressed; E-mails: [email protected] (Nai-Li Wang); [email protected] (Xin-Sheng Yao); Tel: 86-20-85225849; Fax: 86-20-85221559.
Received: 20 July 2008; in revised form: 19 August 2008 / Accepted: 26 August 2008 / Published: 28 August 2008
Article: Flavonoids and a New Polyacetylene from Bidens parviflora Willd.
Molecules 2008, 13, 1931-1941 (PDF format 227 K); DOI: 10.3390/molecules13081931
(This paper belongs to Special Issue on Phenolics and Polyphenolics. Guest Editors: Dr. José Alberto Pereira and Dr. Paula Andrade)


B. Rama Raju and Anil K. Saikia *
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India
E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 21 July 2008; in revised form: 22 August 2008 / Accepted: 22 August 2008 / Published: 28 August 2008
Review: Asymmetric Synthesis of Naturally Occuring Spiroketals
Molecules 2008, 13, 1942-2038 (PDF format 846 K); DOI: 10.3390/molecules13081942
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)

Huan-Mei Guo ¹, Lin-Tong Wang ², Jing-Zhang ³, Pu-Su Zhao ³ and Fang-Fang Jian ^1,3,*
1 Microscale Science institute, Weifang College, Weifang Shandong 261061, P. R. China; E-mail: [email protected] (Huan-Mei Guo)
2 Department of Chemistry, Weifang College, Weifang Shandong 261061, P. R. China; E-mail: [email protected] (Lin-Tong Wang)
3 New Materials & Function Coordination Chemistry Laboratory, Qingdao University of Science and Technology, Qingdao Shandong 266042, P. R. China; E-mails: [email protected] (Jing-Zhang), [email protected] or [email protected] (Pu-Su Zhao)
* Author to whom correspondence should be addressed. E-mail: [email protected]; Tel.: +86-0532-84022948; Fax: +86-0532-84023606.
Received: 31 July 2008; in revised form: 19 August 2008 / Accepted: 25 August 2008 / Published: 1 September 2008
Article: Synthesis, IR Spectra, Crystal Structure and DFT Studies on 1-Acetyl-3-(4-Chlorophenyl)-5-(4-Methylphenyl)-2-Pyrazoline
Molecules 2008, 13, 2039-2048 (PDF format 335 K); DOI: 10.3390/molecules13092039


Lian-Chun Zou ^1,2, Tong-Fei Zhu ^2,3, Hua Xiang ², Lu Yu ², Zhi-Hui Yan ⁴, Shu-Cai Gan ¹, Da-Cheng Wang ^2,*, Sheng Zeng ² and Xu-Ming Deng ^2,*
1 College of Chemistry, Jilin University, Changchun 130062, P.R. China
2 College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P.R. China; E-mails: [email protected] (Hua Xiang), [email protected] (Lu Yu)
3 Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
4 Chongqing Medical and Pharmaceutical College, Chongqing 400030, P.R. China
* Authors to whom correspondence should be addressed; E-mail: [email protected] (Da-Cheng Wang); [email protected] (Xu-Ming Deng); Fax: +86-431-8783-6160.
Received: 30 June 2008; in revised form: 27 August 2008 / Accepted: 28 August 2008 / Published: 1 September 2008
Article: New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora
Molecules 2008, 13, 2049-2057 (PDF format 288 K); DOI: 10.3390/molecules13092049


Biljana Bozin ^1,*, Neda Mimica-Dukic ², Mirjana Bogavac ³, Ljiljana Suvajdzic ¹, Natasa Simin ², Isidora Samojlik ⁴ and Maria Couladis ⁵
1 Faculty of Medicine, Department of Pharmacy, Hajduk Veljkova 3, 21 000 Novi Sad, Serbia; E-mail: [email protected] (Suvajdzic)
2 Faculty of Sciences, Department of Chemistry, Trg D. Obradovica 3, 21 000 Novi Sad, Serbia; E-mails: [email protected] (Mimica-Dukic), [email protected] (Simin)
3 Faculty of Medicine, Department of Gynecology and Obstetrics, B. Cosica 37, 21 000 Novi Sad, Serbia; E-mail: [email protected] (Bogavac)
4 Faculty of Medicine, Department of Pharmacology, Hajduk Veljkova 3, 21 000 Novi Sad, Serbia; E-mail: [email protected] (Samojlik)
5 School of Pharmacy, Department of Pharmacognosy, Panepistimiopolis of Zographou, Zographou 157 71, Athens, Greece; E-mail: [email protected] (Couladis)
* Author to whom correspondence should be addressed. E-mail: [email protected].
Received: 14 July 2008; in revised form: 5 August 2008 / Accepted: 12 August 2008 / Published: 2 September 2007
Article: Chemical Composition, Antioxidant and Antibacterial Properties of Achillea collina Becker ex Heimerl s.l. and A. pannonica Scheele Essential oils
Molecules 2008, 13, 2058-2068 (PDF format 528 K); DOI: 10.3390/molecules13092058


Giovanna Gomez d’Ayala, Mario Malinconico and Paola Laurienzo *
Istituto di Chimica e Tecnologia dei Polimeri, C.N.R.-Via Campi Flegrei, 34- 80078 Pozzuoli (Naples), Italy
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 26 May 2008; in revised form: 2 July 2008 / Accepted: 25 July 2008 / Published: 3 September 2008
Review: Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches
Molecules 2008, 13, 2069-2106 (PDF format 1702 K); DOI: 10.3390/molecules13092069
(This paper belongs to Special Issue on Polysaccharides. Guest Editor: Dr. Shao-ping Li, E-mail: [email protected])


Angela J. Winstead *, Nicole Fleming , Krystal Hart and Deveine Toney
Morgan State University, Department of Chemistry, 1700 E Cold Spring Lane, Baltimore, MD 21251, U.S.A.
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 12 August 2008; in revised form: 27 August 2008 / Accepted: 1 September 2008 / Published: 3 September 2008
Article: Microwave Synthesis of Quaternary Ammonium Salts
Molecules 2008, 13, 2107-2113 (PDF format 185 K); DOI: 10.3390/molecules13092107


Lei Guo ¹, Jin-zhong Wu ^1,2, Ting Han ¹, Tong Cao ³, Khalid Rahman ⁴ and Lu-ping Qin ^1,*
1 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China
2 Academy of integrative medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China; E-mail: [email protected]
3 Department of Biology, College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, P.R. China; E-mail: [email protected]
4 Faculty of Science, School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, England, UK
* Author to whom correspondence should be addressed; E-mail: [email protected]; [email protected].
Received: 15 June 2008; in revised form: 19 August 2008 / Accepted: 3 September 2008 / Published: 4 September 2008
Communication: Chemical Composition, Antifungal and Antitumor Properties of Ether Extracts of Scapania verrucosa Heeg. and its Endophytic Fungus Chaetomium fusiforme
Molecules 2008, 13, 2114-2125 (PDF format 204 K); DOI: 10.3390/molecules13092114


Olcay Bekircan ^1,* and Hakan Bektas ²
1 Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey
2 Department of Chemistry, Giresun University, 28049 Giresun, Turkey; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 15 August 2008; in revised form: 28 August 2008 / Accepted: 1 September 2008 / Published: 10 September 2008
Article: Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones
Molecules 2008, 13, 2126-2135 (PDF format 189 K); DOI: 10.3390/molecules13092126


Hiraku Onishi ^* and Yoshiharu Machida
Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +81-3-5498-5724.
Received: 21 June 2008; in revised form: 25 August 2008 / Accepted: 27 August 2008 / Published: 10 September 2008
Review: In Vitro and In Vivo Evaluation of Microparticulate Drug Delivery Systems Composed of Macromolecular Prodrugs
Molecules 2008, 13, 2136-2155 (PDF format 586 K); DOI: 10.3390/molecules13092136
(This paper belongs to Special Issue on Prodrugs: from Design to Applications. Guest Editor: Dr. Jean Jacques Vanden Eynde)


Nisha Mathew ^1,*, Shailja Misra-Bhattacharya ², Vanamail Perumal ¹ and Kalyanasundaram Muthuswamy ¹
1 Vector Control Research Centre (ICMR), Indira Nagar, Pondicherry-605006, India. E-mails: [email protected] (V. P.), [email protected] (K. M.)
2 Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India. E-mail: [email protected] (S. M-B.)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: 91-413-2272396; Fax: 91-413-2272041.
Received: 8 August; in revised form: 1 September 2008 / Accepted: 3 September 2008 / Published: 11 September 2008
Article: Antifilarial Lead Molecules Isolated from Trachyspermum ammi
Molecules 2008, 13, 2156-2168 (PDF format 200 K); DOI: 10.3390/molecules13092156


Lisa Botes ¹, Francois H. van der Westhuizen ² and Du Toit Loots ^1,2,*
1 School for Physiology, Nutrition and Consumer’s Science, Private Bag X6001, Box 594, Potchefstroom, 2531, South Africa; E-mail: [email protected] (Lisa Botes)
2 School for Physical and Chemical Sciences, North-West University, Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa; E-mails: [email protected] (Francois H. van der Westhuizen)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +27182991818; Fax: +27182991818.
Received: 10 June 2008; in revised form: 22 August 2008 / Accepted: 23 August 2008 / Published: 11 September 2008
Article: Phytochemical Contents and Antioxidant Capacities of Two Aloe greatheadii var. davyana Extracts
Molecules 2008, 13, 2169-2180 (PDF format 190 K); DOI: 10.3390/molecules13092169
(This paper belongs to Special Issue on Phenolics and Polyphenolics. Guest Editors: Dr. José Alberto Pereira and Dr. Paula Andrade)


Ahmed Al-Harrasi * and Salim Al-Saidi
Department of Chemistry, College of Science, Sultan Qaboos University, P.O Box 36, Al-Khod 123, Oman; E-mail: [email protected] (S. A-S.)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +968-92828487; Fax: +968-24141469.
Received: 27 August 2008; in revised form: 10 September 2008 / Accepted: 10 September 2008 / Published: 16 September 2008
Article: Phytochemical Analysis of the Essential Oil from Botanically Certified Oleogum Resin of Boswellia sacra (Omani Luban)
Molecules 2008, 13, 2181-2189 (PDF format 178 K); DOI: 10.3390/molecules13092181


Abbe Maleyki Mhd Jalil and Amin Ismail *
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400, UPM Serdang, Selangor Darul Ehsan, Malaysia
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +603- 89472435; Fax: +603-89426769.
Received: 16 August 2006; in revised form: 29 August 2008 / Accepted: 2 September 2008 / Published: 16 September 2008
Review: Polyphenols in Cocoa and Cocoa Products: Is There a Link between Antioxidant Properties and Health?
Molecules 2008, 13, 2190-2219 (PDF format 273 K); DOI: 10.3390/molecules13092190
(This paper belongs to Special Issue on Phenolics and Polyphenolics. Guest Editors: Dr. José Alberto Pereira and Dr. Paula Andrade)


Claudio Gardana ^1,*, Federico Nalin ² and Paolo Simonetti ¹
1 DiSTAM - Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, 20133 Milan, Italy; E-mail: [email protected] (Paolo Simonetti)
2 Specchiasol s.r.l., Via Rizzi 1/3 - 37012 Bussolengo (Vr), Italy; E-mail: [email protected] (Federico Nalin)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +39 02 50316072; Fax +39 02 50316071.
Received: 1 August 2008; in revised form: 1 September 2008 / Accepted: 9 September 2008 / Published: 18 September 2008
Article: Evaluation of Flavonoids and Furanocoumarins from Citrus bergamia (Bergamot) Juice and Identification of New Compounds
Molecules 2008, 13, 2220-2228 (PDF format 326 K); DOI: 10.3390/molecules13092220
(This paper belongs to Special Issue on Phenolics and Polyphenolics. Guest Editors: Dr. José Alberto Pereira and Dr. Paula Andrade)


Jing-Quan Yuan ^1,2, Xin-Zhou Yang ², Jian-Hua Miao ¹, Chun-Ping Tang ², Chang-Qiang Ke ², Ji-Bao Zhang ², Xiao-Jun Ma ^1,3,* and Yang Ye ^2,*
1 Guangxi Institute of Medicinal Plant, Nanning 530023, P.R. China; E-mail: [email protected] (J-Q. Y), [email protected] (J-H. M.)
2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China; E-mail: [email protected] (X-Z. Y.), [email protected] (C-P. T.), [email protected] (C-Q. K.)
3 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, P.R. China
* Authors to whom correspondence should be addressed; E-mails: [email protected] (X-J. M.); [email protected] (Y. Y.); Tel: +86-7715604464 (X-J. M.); +86-215-0806726 (Y. Y.); Fax: +86- 7715604464 (X-J. M); +86-215-0806726 (Y. Y.).
Received: 18 August 2008; in revised form: 11 September 2008 / Accepted: 12 September 2008 / Published: 22 September 2008
Article: New Triterpene Glucosides from the Roots of Rosa laevigata Michx
Molecules 2008, 13, 2229-2237 (PDF format 288 K); DOI: 10.3390/molecules13092229


Yu-Dong Shen ¹, Shi-Wei Zhang ¹, Hong-Tao Lei ¹, Hong Wang ¹, Zhi-Li Xiao ¹, Yue-Ming Jiang ^2,* and Yuan-Ming Sun ^1,*
1 College of Food Science, South China Agricultural University, Guangzhou 510642, P. R. China; E-mails: [email protected] (Y-D. S), [email protected] (S-W. Z), [email protected] (H-T. W); [email protected] (H. W.); [email protected] (Z-L. X)
2 South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P. R. China
* Authors to whom correspondence should be addressed; E-mails: [email protected] (Y-M. S) or [email protected] (Y-M. J).
Received: 22 August 2008; in revised form: 14 September 2008 / Accepted: 16 September 2008 / Published: 23 September 2008
Article: Design and Synthesis of Immunoconjugates and Development of an Indirect ELISA for Rapid Detection of 3, 5-Dinitrosalicyclic Acid Hydrazide
Molecules 2008, 13, 2238-2248 (PDF format 227 K); DOI: 10.3390/molecules13092238


Mira Popovic ^1,*, Snezana Janicijevic-Hudomal ², Biljana Kaurinovic ¹, Julijana Rasic ² and Svetlana Trivic ¹
1 Department of Chemistry, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia, [email protected] (B. K.)
2 Institute of Pharmacology, Faculty of Medicine Pristina (Kosovska Mitrovica), Serbia
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel: +381214852770; Fax: +38121454065.
Received: 11 August 2008; in revised form: 8 September 2008 / Accepted: 12 September 2008 / Published: 23 September 2008
Article: Effects of Various Drugs on Alcohol-induced Oxidative Stress in the Liver
Molecules 2008, 13, 2249-2259 (PDF format 200 K); DOI: 10.3390/molecules13092249


Mounir Maafi
Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
E-mail: [email protected]. Tel: +44 116 257 7704; Fax: +44 116 257 7287
Received: 14 August 2008; in revised form: 19 September 2008 / Accepted: 19 September 2008 / Published: 25 September 2008
Review: Useful Spectrokinetic Methods for the Investigation of Photochromic and Thermo-Photochromic Spiropyrans
Molecules 2008, 13, 2260-2302 (PDF format 487 K); 10.3390/molecules13092260
(This paper belongs to Special Issue on Spiro Compounds. Guest Editor: Dr. Guy Plourde)


Zhong-Ze Ma ¹, Wei Xu ², Niels H. Jensen ^3,4, Bryan L. Roth ^3,4, Lee-Yuan Liu-Chen ² and David Y. W. Lee ^1,*
1 Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
2 Department of Pharmacology and Center for Substance Abuse Research, School of Medicine, Temple University, 3420 N. Broad St, Philadelphia, PA 19140, USA; E-mail: [email protected] (W. X.), [email protected] (L-Y. L-C.)
3 Department of Pharmacology, University of North Carolina Medical School, Chapel Hill, NC 27599, USA; E-mail: [email protected] (N-H. J.)
4 Center for Neurobiology Division of Medicinal Chemistry and Natural Products, and NIMH Psychoactive Drug Screening Program, University of North Carolina Medical School, Chapel Hill, NC 27599, USA; E-mail: [email protected] (B-L. R.)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +1-617-855-2038; Fax: +1-617-855-2040.
Received: 29 August 2008; in revised form: 15 September 2008 / Accepted: 16 September 2008 / Published: 25 September 2008
Communication: Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor
Molecules 2008, 13, 2303-2312 (PDF format 231 K); DOI: 10.3390/molecules13092303


Chun-Wei Kuo, Chun-Chao Wang, Veerababurao Kavala and Ching-Fa Yao *
Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +886-2-2930-9092; Fax: +886-2-2932-4249.
Received: 22 August 2008; in revised form: 10 September 2008 / Accepted: 10 September 2008 / Published: 25 September 2008
Article: Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
Molecules 2008, 13, 2313-2325 (PDF format 305 K); DOI: 10.3390/molecules13092313


Roman Sívek, Filip Bureš *, Oldřich Pytela and Jiří Kulhánek
Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, nám. Čs. legií 565, Pardubice, CZ-532 10, Czech Republic
* Author to whom correspondence should be addressed; E-mail: [email protected].
Received: 2 September 2008; in revised form: 10 September 2008 / Accepted: 12 September 2008 / Published: 25 September 2008
Article: Imidazole-based Potential Bi- and Tridentate Nitrogen Ligands: Synthesis, Characterization and Application in Asymmetric Catalysis
Molecules 2008, 13, 2326-2339 (PDF format 591 K); DOI: 10.3390/molecules13092326

Molecules (ISSN 1420-3049)