Special Issue "Aporphines and Oxoaporphines"
[Call for Papers] [List of Keywords]
Deadline for paper submission: 30 June 2009

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Keywords:
medicinal chemistry, natural products, photochemistry reactivity, aporphine and oxoaporphine, oxoisoaporphine, coumarins

Manuscript Preparation:
Manuscripts should be prepared according to the Instructions for Authors (http://www.mdpi.org/molecules/publguid.htm) and submitted before 30 June 2009
by e-mail to [email protected] with a copy to [email protected] and [email protected]. The subject title of the message should be
"Manuscript for Special Issue on Aporphines and Oxoaporphines".

Review papers to be considered and published:


Research articles to be considered and published:
Manuscript ID: molecules-aporph-20080915-tw-Chen
Type of Paper: Article
Tentative Title: Liriodenine Compound Inhibits in vitro Dengue Virus Replication or Anti-dengue Viral Activity of Liriodenine Derivatives
Authors: Chung-Yi Chen
Affiliation: School of Medicine and Health Sciences, Fooyin University, Kaohsiung Hsien 831, Taiwan
E-mail: [email protected]
Abstract: Dengue viruses (DV) are mosquito-borne flaviviruses that cause a large number of human infections worldwide each year. No vaccines or chemotherapeutics are currently available.  Therefore, the increasing number of outbreaks of dengue hemorrhagic fever caused by DV infection brings out an urgent need to develop potent anti-DV agents. A collection of hundreds of pure components isolated from the native plants of Taiwan, we found purified compounds of Michelia alba for the activities to suppress DV replication using a stable subgenomic dengue virus replicon system that expressed firefly luciferase reporter and neomycin phosphotransferase (Neo) genes in BHK21 cell lines. The results indicated that the liriodenine (aporphime) compound can significantly reduce luciferase-reporter activity in a dose dependent manner. The 50% effective concentration (EC50) was 22.0 +/- 2.0 mM and no mitrochondrial toxicity was observed at this effective concentration.  Furthermore, the liriodenine compound exhibited a synergistic antiviral activity in combination with IFN-α in DV replicon system, in which the antiviral response was better than IFN-αalone. Collectively, these data suggested that this novel inhibitor could be developed for potential treatment of DV infection through combination with other therapeutics.


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