Abeer M Al-Ghananeem † and Peter A Crooks*
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington,
Kentucky 40536, USA; † e-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 10 February 2007; in revised form: 5 March 2007 / Accepted: 5 March 2007 / Published: 8 March 2007
Review: Phase I and Phase II Ocular Metabolic Activities and the Role of Metabolism in Ophthalmic Prodrug and Codrug Design and Delivery
Molecules 2007, 12, 373-388 (PDF format 80 K)


Elina Sievänen
University of Jyväskylä, Department of Chemistry, P.O. Box 35, FIN-40014 University of Jyväskylä, Finland; E-mail: [email protected]
Received: 6 June 2007; in revised form: 13 August 2007 / Accepted: 14 August 2007 / Published: 16 August 2007
Review: Exploitation of Bile Acid Transport Systems in Prodrug Design
Molecules 2007, 12, 1859-1889 (PDF format 159 K)
(This paper also belongs to Special Issue on Bile acids,edited by Dr. Erkki Kolehmainen)


Paula Gomes ^1,*, Nuno Vale ¹ and Rui Moreira ²
1 Centro de Investigação em Química da Universidade do Porto, Departamento de Química, Faculdade de Ciências, Universidade do Porto, Porto, Portugal
2 Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal
* Corresponding author: R. Campo Alegre 687, P-4169-007 Porto, Portugal; Phone: + 351220402563; Fax: +351 220402659; E-mail: [email protected]
Received: 6 October 2007; in revised form: 8 November 2007 / Accepted: 9 November 2007 / Published: 12 November 2007
Review: Cyclization-activated Prodrugs
Molecules 2007, 12, 2484-2506 (PDF format 158 K)


Yoshifumi Murata ^1,*, Daisaku Jinno ¹, Dongchun Liu ², Takshi Isobe ¹, Kyouko Kofuji ¹ and Susumu Kawashima ¹
1 Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
2 Department of Pharmacognosy, Shenyang Pharmaceutical University, Wen Hua Road 103, mailbox 48, Shenhe, Shenyang, 110016, PRC
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: +81-076-229-6184; Fax: +81-076-229-2781
Received: 17 November 2007; in revised form: 27 November / Accepted: 27 November 2007 / Published: 29 November 2007
Full Paper: The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate
Molecules 2007, 12, 2559-2566 (PDF format 109 K)


Antonio Di Stefano*, Piera Sozio and Laura Serafina Cerasa
Department of Drug Sciences, “G. d'Annunzio” University, School of Pharmacy, Via dei Vestini 31, 66100 Chieti, Italy
* Author to whom correspondence should be addressed. Tel.: +39-871-3554708; fax: +39-871-3554706; E-mail: [email protected]
Received: 4 December 2007; in revised form: 11 January 2008 / Accepted: 11 January 2008 / Published: 16 January 2008
Review: Antiparkinson Prodrugs
Molecules 2008, 13, 46-68 (PDF format 172 K)


Andrea Brioschi ^1,*, Gian Paolo Zara ², Sara Calderoni ³, Maria Rosa Gasco 4 and Alessandro Mauro ^1,5
1 Istituto Auxologico Italiano, IRCCS – Department of Neurology – Ospedale S. Giuseppe, Piancavallo, PO. Box 1 – 28921 Verbania, Italy
2 University of Torino – Department Anatomy Pharmacology Forensic Medicine – Torino, Italy
3 Istituto Auxologico Italiano, IRCCS – Department of Neurology – Laboratory of Clinical Neurobiology – Verbania, Italy
4 Nanovector S.r.l. – Torino, Italy
5 University of Torino – Departement of Neurosciences – Torino, Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 4 January 2008; in revised form: 31 January 2008 / Accepted: 1 February 2008 / Published: 1 February 2008
Review: Cholesterylbutyrate Solid Lipid Nanoparticles as a Butyric Acid Prodrug
Molecules 2008, 13, 230-254 (PDF format 148 K)


Francesca Leonelli, Angela La Bella, Luisa Maria Migneco and Rinaldo Marini Bettolo*
Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, Università degli Studi di Roma "La Sapienza”, P.le Aldo Moro 5, BOX n. 34 ROMA 62, I-00185 Roma, Italy; E-mails: [email protected], [email protected], [email protected]
†Dedicated to the Memory of Prof. Vittorio Crescenzi [1]
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 29 January 2008; in revised form: 11 February 2008 / Accepted: 11 February 2008 / Published: 12 February 2008
Review: Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates^†
Molecules 2008, 13, 360-378 (PDF format 106 K)


Amin I. Kassis*, Houari Korideck, Ketai Wang, Pavel Pospisil and S. James Adelstein
Department of Radiology, Harvard Medical School, Armenise Building, Room D2-137, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
*Author to whom correspondence should be addressed. Telephone: (617) 432-7777; Fax: (617) 432-2419; E-mail: [email protected]
Received: 6 February 2008 / Revised version received: 15 February 2008 / Accepted: 15 February 2008 / 18 February 2008
Review: Novel Prodrugs for Targeting Diagnostic and Therapeutic Radionuclides to Solid Tumors
Molecules 2008, 13, 391-404 (PDF format 632 K)


Helieh S. Oz* and Jeffrey L. Ebersole
Center for Oral Health Research, College of Dentistry and Department of Internal Medicine, University of Kentucky, Medical Center, 800 Rose Street, Lexington, KY 40536, USA; E-mail: [email protected] (Jeffrey L. Ebersole)
* Author to whom correspondence should be addressed; E-mails: [email protected]; [email protected]; Phone: +1 (859) 323-0887
Received: 26 January 2008; in revised form: 20 February 2008 / Accepted: 21 February 2008 / Published: 27 February 2008
Review: Application of Prodrugs to Inflammatory Diseases of the Gut
Molecules 2008, 13, 452-474 (PDF format 142 K)
Corrigendum: Correction to Oz, H.S.; Ebersole, Jeffrey L. Application of Prodrugs to Inflammatory Diseases of the Gut. Molecules 2008, 13, 452-474
Received: 31 March 2008 / Accepted: 1 April 2008 / Published: 1 April 2008
Molecules 2008, 13, 771 (PDF format 18 K)


Ana L. Simplício ^1,2,*, John M. Clancy ³ and John F. Gilmer ³
1 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal
2 IBET, Apartado 12, 2781-901 Oeiras, Portugal
3 School of Pharmacy, Trinity College, Dublin 2, Ireland; E-mails: [email protected]; [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 14 December 2007; in revised form: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
Review: Prodrugs for Amines
Molecules 2008, 13, 519-547 (PDF format 165 K)


Man Chin Chung ^1,*, Elizabeth Igne Ferreira ^2,†, Jean Leandro Santos ^l,2, Jeanine Giarolla ², Daniela Gonçales Rando ², Adélia Emília Almeida ¹, Priscila Longhin Bosquesi ¹, Renato Farina Menegon ¹ and Lorena Blau ¹
1 Lapdesf - Laboratório de Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas - UNESP Rodovia Araraquara-Jaú Km 1,
14801-902, Brazil
2 LAPEN – Laboratório de Planejamento e Síntese de Quimioterápicos Potencialmente Ativos em Endemias Tropicais, Departamento de Farmácia, Faculdade de Ciências Farmacêuticas – USP/SP, R. Prof. Lineu Prestes, 580, B-13S, Cidade Universitária, São Paulo, 05508-900, Brazil; † E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 11 January 2008; in revised form: 12 March 2008 / Accepted: 12 March 2008 / Published: 19 March 2008
Review: Prodrugs for the Treatment of Neglected Diseases
Molecules 2008, 13, 616-677 (PDF format 462 K)


Vassilis E. Kouloulias ^1,* and John R. Kouvaris ²
1 Kapodistrian University, 2nd Radiology Department, Medical School, Attikon University Hospital, Rimini 1, Xaidari, Greece
2 Aretaieion University Hospital, 1st Radiology Department, Radiotherapy Unit, Athens, Greece.
* Author to whom correspondence should be addressed; E-mail: [email protected]; Fax: +302105326418
Received: 1 February 2008; in revised form: 16 April 2008 / Accepted: 16 April 2008 / Published: 18 April 2008
Review: Cytoprotective Efficacy of Amifostine Against Radiation-Induced Rectal Toxicity: Objective and Subjective Grading Scales for Radiomucositis
Molecules 2008, 13, 892-903 (PDF format 103 K)


Barbara Pavan ^1,*, Alessandro Dalpiaz ², Nunzia Ciliberti ², Carla Biondi ¹, Stefano Manfredini ² and Silvia Vertuani ²
1 University of Ferrara, Department of Biology, General Physiology Section, via L. Borsari 46, 44100, Ferrara, Italy
2 University of Ferrara, Department of Pharmaceutical Sciences, via Fossato di Mortara 19, 44100, Ferrara, Italy
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +39-0532-455476; Fax: +39-0532-207143
Received: 1 February 2008; in revised form: 1 April 2008 / Accepted: 30 April 2008 / Published: 1 May 2008
Review: Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach
Molecules 2008, 13, 1035-1065 (PDF format 225 K); DOI: 10.3390/molecules13051035


Marinella G. Sandros ^1,3, Chady B. Sarraf ^4,5 and Maryam Tabrizian ^1,2,3,*
1 Department of Biomedical Engineering, McGill University, 3775 University Street, Montreal, QC, Canada H3A2B4
2 Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada, H3A 2B2
3 Center for Biorecognition and Biosensors, McGill Institute for Advanced Materials, 3775 University Street, Montreal, QC, Canada H3A2B4
4 Department of Medical Education, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
5 St. Michael’s Medical Center, 111 Central Avenue, Newark, NJ 070102, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 5 February 2008; in revised form: 14 May 2008 / Accepted: 14 May 2008 / Published: 14 May2008
Review: Prodrugs in Cardiovascular Therapy
Molecules 2008, 13, 1156-1178 (PDF format 423 K); DOI: 10.3390/molecules13051156


Hiraku Onishi ^* and Yoshiharu Machida
Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +81-3-5498-5724.
Received: 21 June 2008; in revised form: 25 August 2008 / Accepted: 27 August 2008 / Published: 10 September 2008
Review: In Vitro and In Vivo Evaluation of Microparticulate Drug Delivery Systems Composed of Macromolecular Prodrugs
Molecules 2008, 13, 2136-2155 (PDF format 586 K); DOI: 10.3390/molecules13092136

Molecules Manuscript ID: prodrugs-20071204-Montenegro-it
Type of the paper: Review
Tentative Title: The prodrug approach: a strategy to improve drug skin permeation
Authors: L. Montenegro *, C. Carbone, G. Puglisi
Department of Pharmaceutical Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
E-mail: [email protected]
Abstract: The skin is regarded as a valuable portal for drug delivery. However, drug skin permeation is strongly limited by the formidable barrier function of the skin and by the unsuitable physicochemical properties of most drugs. Therefore many strategies have been proposed to improve drug skin permeability such as the prodrug approach. The prodrug concept involves the chemical modification of a drug into a bioreversible form in order to change its pharmaceutical and pharmacokinetic properties and thereby enhancing its skin permeation and therapeutic efficacy. In this review prodrugs which have been investigated to improve topical and transdermal drug delivery are considered along with their potential applications in the pharmaceutical field.

Molecules Manuscript ID: prodrugs-20071221-Rusnati-it
Type of the paper: Review
Tentative Title: Polysulfated/Polysulfonated Compounds for the Development of Drugs at the Crossroad of Tumor and Infectious Dideases
Authors: Chiara Urbinati, Paola Chiodelli, Marco Presta and Marco Rusnati
Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
E-mail: [email protected]
Abstract: Polyanionic compounds are an heterogeneous group of synthetic, semisynthetic or natural molecules whose prototypes are polysulfated heparin and polysulfonated suramin. Polyanionic compounds can structurally vary for backbone structure and length and for  number and disposition of sulfated/sulfonated groups. Different combinations of all these features confer to polyanionic compounds the capacity to bind with a variable degree of specificity and affinity many proteins such as enzymes, proteases, extracellular matrix components, cytokines, chemokines, growth factors and their receptors. Also, polyanionic compounds bind different components of pathogenic microorganisms, mainly viruses. Polyanionic compounds mirror the binding capacities of cell- or extracellular matrix-associated heparan sulfate proteoglycans, that act indeed as receptors for many of the proteins cited above. On these bases, polyanionic compounds have been taken in considerations as inhibitors of different pathological processes, in particular tumor growth, metastatization and angiogenesis, infection, virus replication, leukocyte recruitment  and inflammation. Being some of these processes overlapping, polyanionic compounds may act as multitarget drugs, thus able to control a given disease by blocking different pathological processes simultaneously. Here we discuss this possibility in light of the available literature data.

Yasuhiro Tsume ¹, Balvinder S. Vig ², Jing Sun ³, Christopher P. Landowski ⁴, John M. Hilfinger ⁵, Chandrasekharan Ramachandran ¹ and Gordon L. Amidon 1,*
1 Department of Pharmaceutical Science, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA; E-mails: [email protected]; [email protected]
2 Pharmaceutical Research Institute, Bristol-Myers Squibb Company, New Brunswick, NJ 08502; E-mail: [email protected]
3 Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA; Email: [email protected]
4 Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012 Bern, Switzerland; E-mail: [email protected]
5 TSRL, Inc. Ann Arbor, Michigan 48108, USA; Email: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Phone: +1-734-764-2440; Fax: +1-734-763-6423.
Received: 12 June 2008 / Accepted: 27 June 2008 / Published: 28 June 2008
Article: Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters
Molecules 2008, 13, 1441-1454 (PDF format 132 K); DOI: 10.3390/molecules13061427
(This paper belongs to Special Issue on 5-Fluorouracil. Guest Editor: Dr. Francesco Puoci, E-mail: [email protected])

Francesco Puoci ^1,*, Francesca Iemma ¹, Giuseppe Cirillo ¹, Nevio Picci ¹, Pietro Matricardi ² and Franco Alhaique ²
1 Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
2 Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, University “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy
* Author to whom correspondence should be addressed; email: [email protected]; Tel. (+39) 0984493151, fax (+39) 0984493151
Received: 21 March 2007; in revised form: 13 March 2007 / Accepted: 16 April 2007 / Published: 18 April 2007
Full Paper: Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids
Molecules 2007, 12, 805-814 (PDF format 69 K)


Jesper Østergaard* and Claus Larsen^†
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen O, Denmark; †E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 28 September 2007; in revised form: 29 October 2007 / Accepted: 29 October 2007 / Published: 30 October 2007
Full Paper: Bioreversible Derivatives of Phenol. 1. The Role of Human Serum Albumin as Related to the Stability and Binding Properties of Carbonate Esters with Fatty Acid-like Structures in Aqueous Solution and Biological Media
Molecules 2007, 12, 2380-2395 (PDF format 107 K)


Jesper Østergaard* and Claus Larsen^†
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen O, Denmark; †E-mail: [email protected]
* Author to whom correspondence should be addressed. E-mail: [email protected]
Received: 28 September 2007; in revised form: 29 October 2007 / Accepted: 29 October 2007 / Published: 30 October 2007
Full Paper: Bioreversible Derivatives of Phenol. 2. Reactivity of Carbonate Esters with Fatty Acid-like Structures Towards Hydrolysis in Aqueous Solutions
Molecules 2007, 12, 2396-2412 (PDF format 156 K)


Ebru Mete ¹, Halise Inci Gul ^2,* and Cavit Kazaz ¹
1 Department of Chemistry, Faculty of Arts and Sciences, Ataturk University, 25240, Erzurum, Turkey
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey
* Author to whom correspondence should be addressed; E-mail: [email protected] or [email protected]; Tel: +90-442-2311539; Fax: +90-442-2360962
Received: 29 October 2007; in revised form: 26 November 2007 / Accepted: 10 December 2007 / Published: 12 December 2007
Full Paper: Synthesis of 1-Aryl-3-phenethylamino-1-propanone Hydrochlorides as Possible Potent Cytotoxic Agents
Molecules 2007, 12, 2579-2588 (PDF format 80 K)


Nelly Alejandra Espinoza-González ¹, Oliverio Welsh ¹, Noemi Waksman de Torres ², Norma Cavazos-Rocha ², Jorge Ocampo-Candiani ¹, Salvador Said-Fernandez ³, Gerardo Lozano-Garza ³, Sung-Hak Choi ⁴ and Lucio Vera-Cabrera ^1,*
1 Servicio de Dermatología, Hospital Universitario “Dr. José E. González” Ave. Madero y Gonzalitos S/N Col. Mitras Centro Monterrey, N.L. México 64460; E-mail: [email protected]
2 Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León,
Ave. Madero y Dr. Eduardo Aguirre Pequeño S/N, Col Mitras Centro, Monterrey, N.L., México 64460
3 Centro de Investigación Biomédica del Noreste (CIBIN) del IMSS, 2 de Abril y San Luis Potosí, Col. Independencia, Monterrey, N.L., México 64720
4 Research Laboratory, Dong-A Pharmaceutical Co., Ltd., Yongin, and College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
* Author to whom correspondence should be addressed: E-mail: [email protected]
Received: 2 November 2007; in revised form: 29 December 2007 / Accepted: 29 December 2007 / Published: 11 January 2008
Full Paper: Efficacy of DA-7218, a New Oxazolidinone Prodrug, in the Treatment of Experimental Actinomycetoma Produced by Nocardia brasiliensis
Molecules 2008, 13, 31-40 (PDF format 215 K)


Marcin Sobczak*, Ewa Witkowska, Ewa Olędzka and Waclaw Kolodziejski
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland; E-mails: [email protected] (E. Witkowska),
[email protected] (E. Olędzka), [email protected] (W. Kolodziejski)
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel.: +48 22 572 07 55; Fax: +48 22 572 07 84.
Received: 14 December 2007; in revised form: 16 January 2008 / Accepted: 16 January 2008 / Published: 18 January 2008
Full Paper: Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
Molecules 2008, 13, 96-106 (PDF format 94 K)


Michael N. Levine ¹, Luke D. Lavis ² and Ronald T. Raines ^1,2,*
1 Department of Biochemistry, University of Wisconsin–Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA
2 Department of Chemistry, University of Wisconsin–Madison, 1101 University Avenue, Madison, WI 53706-1322, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 19 January 2008 / Accepted: 30 January 2008 / Published: 31 January 2008
Full Paper: Trimethyl Lock: A Stable Chromogenic Substrate for Esterases
Molecules 2008, 13, 204-211 (PDF format 140 K)


Karl Vollmann, Ramatullah Qurishi, Jörg Hockemeyer and Christa E. Müller*
Pharma-Center Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany; http://www.pharmazentrum.uni-bonn.de/ and http://www.pharma.uni-bonn.de/pharmchem/
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received:  29 January 2008; in revised form: 11 February 2008 / Accepted: 11 February 2008 / Published: 12 February 2008
Full Paper: Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A_2A Receptor Antagonist MSX-2
Molecules 2008, 13, 348-359 (PDF format 96 K)


Lorena Blau ¹, Renato Farina Menegon ¹, Elizabeth Igne Ferreira ², Antonio Gilberto Ferreira ³, Elisangela Fabiana Boffo ³, Leila Aley Tavares ³, Vladimir Constantino Gomes Heleno ^3,4,* and Man-Chin Chung ^1,*
1 Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CP 502 – 14801-902, Araraquara, SP, Brazil; E-mails: [email protected]; [email protected]
2 Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CP 66083 – 05389-970, São Paulo, SP, Brazil; E-mail: [email protected]
3 Departamento de Química, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de São Carlos, CP 676 – 13565-905, São Carlos, SP, Brazil; E-mails: [email protected]; [email protected]; [email protected]
4 Núcleo de Pesquisas em Ciências Exatas e Tecnológicas – Universidade de Franca, CP 82 – 14404-600, Franca, SP, Brazil
* Authors to whom correspondence should be addressed; E-mail for V.C.G.H.: [email protected]; Phone: +55 16 37118871; Fax: +55 16 37118878; E-mail for M-C.C.: [email protected]; Phone: +55 16 33016962; Fax: +55 16 33016960.
Received: 12 March 2008; in revised form: 6 April 2008 / Accepted: 7 April 2008 / Published: 10 April 2008
Full Paper: Synthesis and Total ¹H- and ¹³C-NMR Assignment of Cephem Derivatives for Use in ADEPT Approaches
Molecules 2008, 13,  841-854 (PDF format 131 K)

Manuscript ID: prodrugs-20080204-Prokai-us
Type of the paper: Full Paper
Tentative title: TRH prodrugs as CNS agents
Author: Katalin Prokai-Tatrai, Ph. D.
Res. Assoc. Professor
Pharmacology & Neuroscience
University of North Texas Health Science Center at Fort Worth
3500 Camp Bowie Blvd.
Fort Worth, Texas 76107-2699
phone: (817) 735 0617
email: [email protected]