Chair: 2008 Gordon
Research Conference on Bioanalytical Sensors at Bryant University,
Smithfield, RI, USA
BIOANALYTICAL SENSORS
June 29 - July 4, 2008Bryant University, Smithfield, RI
http://www.grc.org/programs.aspx?year=2008&program=biosens
Deadline for Paper Submission: 31 October 2008
SummaryAs defined for this special issue, toxins are a
subset of poisonous materials – bio-organic compounds of biological
origin that have a deleterious effect on humans and other higher
animals. Although infectious agents can be detected and
identified based on their nucleic acid sequences, the presence of an
active toxin cannot necessarily be determined based entirely on the
presence of its gene sequence. Furthermore, the short timeframe
from exposure to clinical manifestation (minutes to hours) requires a
rapid turnaround for mitigation and treatment of the toxic
effects. Thus, rapid and sensitive sensors are needed to test not
only for the presence of toxin, but also its concentration and
activity. This special issue is devoted to describing the latest
research in development and application of sensors for
detection/identification of toxins as well as for diagnosis of
intoxication. Specific topics of interest include: basic,
proof-of-concept studies of new methods, materials, and systems for
toxin detection/identification; use of toxin sensors in new
environments or matrices; automation of state-of-the-art toxin sensors;
use of sensors to diagnose intoxication, and blind testing of extant
toxin sensors with unknown samples. Reviews of systems with
demonstrated efficacy for toxin detection are also welcome.
Keywords
toxin, biotoxin, toxic agent, biomolecule, biosensor, detection, immunoassay, immunosensor, antibody, receptor
Planned Papers
Tentative Title: NMR-thermometers and their Feasibility Evaluation for Different Applications
Author: Anastasia Vyalikh, Department of Surface Modification, Leibniz Institute of Polymer Research Dresden
Phone: +49 (0)351 4658432, Fax: +49 (0)351 4658231, Hohe Str. 6, D-01069 Dresden, Germany
Tentative Title: Fiber Optic Sensor for Salmonella Detection
Author: Arun Bhunia, BVSc, PhD, Professor of Molecular Food Microbiology
Department of Food Science, Purdue University, 745 Agriculture Mall Dr., West Lafayette, IN 47907
Tel: (765) 494-5443, FAX: (765) 494-7953, E.mail:
[email protected], http://www.foodsci.purdue.edu/research/labs/bhunia/
Title:
Electrochemical Immunosensor Based on Polythionine/Gold Nanoparticles for the Determination of Aflatoxin B1Authors: Joseph
H.O. Owino, Omotayo A. Arotiba, Nicolette Hendricks, Everlyne A. Songa,
Nazeem Jahed, Tesfaye T. Waryo, Priscilla G .L. Baker and Emmanuel I.
Iwuoha*SensorLab, Department of Chemistry, University of Western Cape, Private Bag X17, Bellville 7535, Cape Town, South Africa
* Author to whom correspondence should be addressed. E-mail:
[email protected]Abstract:
An immunosensor based on gold nanoparticles (AuNP) and polythionine
modified glassy carbon electrode (GCE) for determination of Aflatoxin
B1 (AFB1) was developed. Aflatoxin B1-BSA conjugate was immobilised on
the modified GCE. Horseradish peroxidase (HRP) and Bovine serum albumin
were used to block sites against non-specific binding. Competition
reaction was allowed to take place between the free AFB1 and
AFB1-conjugate for the binding sites of the anti-aflatoxin B1 antibody.
Cyclic voltammetry (CV) was employed to characterize the
electrochemical properties of the modified process. Differential pulse
voltammetry (DPV) was used to monitor the analytical signal. HRP was
chosen due to its catalytic properties. The current response decreased
with an increase in AFB1 concentration in the range of 0.6-2.4 ng/mL
with a limit of detection of 0.07 and 0.16 ng/mL for HRP and BSA
blocked immunosensors respectively. The proposed method eliminates the
use enzymatic labels.
Keywords: Immunosensor; Gold nanoparticles; Aflatoxin B1; Polythionine; Horseradish peroxidise (HRP)
Submission
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MDPI - Matthias Burkhalter - 18 September 2008