3-(2,5-Cyclohexadienyl)-L-alanine (1,4-Dihydro-L-phenylalanine)
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Its Synthesis and Behaviour in the Phenylalanine Ammonia-Lyase Reaction

Table 3:

Inhibitors of PAL.

 
 
inhibitor
    Ki [µM] 
Ki / Km (phe)
3-cyclohexyl-L-alanine 1)
2.3
8.5
(2S,E)-2-amino-4-methylhex-4-enoic acid 1)
30
111
D,L-allylglycine 1)
280
1037
L-3-cyanoalanine 1)
50
185
trans,trans-sorbic acid 1)
10
37
(S)-2-aminooxy-3-phenyl-propanoic acid 2)
0.014
0.0003
(R)-(1-amino-2-phenylethyl)phosphonic acid 2)
1.5
0.32
2,5-dihydro-L-phenylalanine 3)
30.6
0.75
1,4-dihydro-L-phenylalanine 3)
157
3.8

1) PAL from maize; K. R. Hanson, E. A. Havir and C. Ressler Biochemistry 1979, 18, 1431.
2) PAL from buckwheat; J. Zon´ and N. Amrhein Liebigs Ann. Chem. 1992, 625.
3) Recombinant PAL from parsley.

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