Fourth International Electronic Conference on Synthetic Organic Chemistry (ECSOC-4), www.mdpi.org/ecsoc-4.htm, September 1-30, 2000

[A0085]

Amino Acid-Derived Cyclic Phosphonamides as Potential HIV-Protease Inhibitors

Kevin T. Sprott and Paul R. Hanson*

Department of Chemistry, University of Kansas, Lawrence, KS 66045
E-mail: [email protected]

Received: 16 August 2000 / Uploaded: 20 August

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Table of Contents

Amino Acid-Derived Cyclic Phosphonamides as Potential HIV-Protease Inhibitors

RCM Strategy to Phosphorus-Based Potential .HIV Protease Inhibitors

RCM Strategy to Cyclic Phosphonamides

Phosphonamidic Anhydrides

Methyl, Vinyl, and Bicyclic Anhydrides

P-Heterocycles via RCM

Amino Acid-Derived P-Heterocycles

Utilization of P(III) Chemistry

Internal Amino Acid Centers on P-Heterocycles

Phosphonamides with Two External Amino Acids

1,4-Diamine Strategy

Synthesis of Amino Acid-Derived 1,4-Diamine

N,N�- a-Branched Cyclic Phosphonamides

N,N�-b-Branched Cyclic Phosphonamides

Intermolecular Olefin Metathesis

Template Promoted RCM/Amide Hydrolysis Sequence En Route to 1,4-Diamines

Novel P-Heterocycles

Acknowledgements

Author: Paul Hanson

Email: [email protected]

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