Editorial Office
IJMS Editorial Office
Molecular Diversity Preservation International
Kandererstrasse 25, CH-4057 Basel, Switzerland
Tel. +41-61-683-7734; Fax: +41-61-302-8918
Address manuscript submissions to: Dr. Yuan Gao, E-mail:
[email protected]
Guest Editor
Prof. Dr.
Kurt A. Jellinger
Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna,
Austria
Tel. +43-1-5266534; Fax: +43-1-5266534
E-mail:
[email protected]
Rationale for the
special issue on "Advances in Molecular Neuropathology"
Dear Colleagues,
During the recent years,
considerable
progress has been achieved in molecular genetics, pathogenesis and
pathology of many nervous system disorders, based on new and modern
technologies and animal models.
In the field of tumors
of the CSN,
the new 2007 classification, based on modern molecular genetics,
immunocytochemistry and proteomics, has provided deeper insights into
the pathogenesis and molecular pathobiology of CNS malignancies and has
listed several new entities to the existing grading system, thus
broadening the diagnostic spectrum and prognostic factors.
Modern research in inflammatory
disorders
of the nervous system has been focused on different types of multiple
sclerosis (MS), their molecular and immunopathology, as well as on new
molecular genetic findings and animal models of MS and related
disorders, such as neuromyelitis optica and immun-mediated
neuropathies, neuro-AIDS (CNS-HIV), and the relations between
neuroinflammation and neurodegeneration.
One of the fields of most intensive and successful research is neurodegeneration and dementias,
where many new phenotypes have been detected and classified using
modern molecular genetics and animal and cellular models. Although the
etiology and pathogenesis of Alzheimer disease and many other
neurodegenerative and dementing disorders are still far from being
elucidated, recent studies have provided important and meaningful
results about the role of protein misfolding in neurodegeneration, eg,
in the relationship of β-amyloid and tau protein in the
pathogenesis of
brain aging and Alzheimer disease, the role of α-synuclein and tau in
neurodegeneration. Modern research has detected new forms of
neurodegenerative disorders, such as the TDP-43-pathies, but has also
provided new insights into the pathogenesis and molecular pathology of
well-known entities, such as CAG repeat disorders, motor neuron
diseases, prion diseases, peroxisomal and mitochondrial disorders.
The present special issue will present various aspects of
modern research in molecular neuropathology in order to provide new
impacts for further research in this up-to-date field of neurosciences.
Kurt A. Jellinger