Search Result

Molecules 2000, 5, M175

2,4-Dinitrophenylhydrazine-benzo-9-crown-3

A. Moghimi¹*, M. Faal Rastegar² and M. Ghandi²

1) Department of Chemistry, University of Imam Hosien, Tehran, Iran

2) Deparment of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran, E-mail: [email protected]

Received: 12 June 2000 / Accepted: 28 September 2000 / Published: 25 December 2000

In the course of our recent studies on the synthesis, solid phase structure, solution and solid phase ¹³C CPMAS [1], and its application in Ion Selective Electrodes [2] of the smallest benzo crown ether, Benzo-9-Crown-3, B9C3, we accomplished the synthesis of B9C3 derivative 3. The B9C3 derivative 3 would be useful for the spectrophotometric complexatiion studies. The starting crown ether 2 was prepared by the formylation of B9C3 according to the known procedure [3] using hexamine and trifluoroacetic acid.

To a solution of 2 (0.83g, 4 mmol) in methanol (10 ml) was added dropwise a solution of 2,4-dinitrophenyl hydrazine (0.79 g, 4 mmol) in a mixture of concentrated H₂SO₄ (2.5 ml), H₂O (3.5 ml) and methanol (11.5 ml) with stirring for 10 min. at room temprature. The orange-red precipitate that separated out was filtered off, washed with hot ethanol to afford 1.4 g of title compound 3 in 90% yield.

M.p. 224-226 °C

¹H NMR (250 MHz, DMSO-d₆): 11.57 (s, 1H, NH), 8.83 (d, ⁴J_ab=2.5 Hz, 1H, Ha), 8.5 (s, 1H, N=CH), 8.33 (dd, ³J_bc=9.6 Hz, ⁴J_ba=2.5 Hz, 1H, Hb), 8.05 (d, ³J_cb=9.6 Hz, 1H, Hc), 7.40 (d, ⁴J_fg=1.7 Hz, 1H, Hf), 7.34 (dd, ³J_gh=9.3 Hz, ⁴J_gf=1.7 Hz, 1H, Hg), 7.04 (d, J_hg=9.3 Hz, Hh), 4.43 (m, 2H, CH₂O), 4.34 (m, 2H, CH₂O), 3.84 (m, 4H, CH₂O).

¹³C NMR (62.9 MHz, DMSO-d₆): 154.1, 152.0, 149.6, 145.3, 137.7, 130.6, 130.1, 129.8, 124.3, 123.8, 123.5, 122.2, 117.6, 74.5, 73.3, 72.6, 72.3.

FTIR (cm^-1, KBr): 3286m, 3091w, 3030w, 2341w, 1614s, 1585s, 1564w, 1512s, 1490s, 1452w, 1418m, 1320s, 1300s, 1280m, 1253m, 1217w, 1166w, 1130m, 1087m, 1043m, 885w, 830m, 742w, 711w, 638w.

EI MS (70 eV): 388 (m^+., 100), 164 (55), 137 (25), 107 (25), 79 (50), 63 (35), 45 (30).

References

1. Buchanan, G.W.; Driega, A.B.; Moghimi, A.; Bensimon, C. Can. J. Chem. 1993, 71, 1983-1989.

2. Ganjali, M. R.; Moghimi, A.; Shamsipur, M. Anal. Chem. 1998, 70, 5259-5263.

3. Wada, F.; Hirayama, H. Bull. Chem. Soc. Jpn. 1980, 53, 1473-1474.

Sample availability: available from the authors and MDPI.

1.	Buchanan, G.W.; Driega, A.B.; Moghimi, A.; Bensimon, C. Can. J. Chem. 1993, 71, 1983-1989.
2.	Ganjali, M. R.; Moghimi, A.; Shamsipur, M. Anal. Chem. 1998, 70, 5259-5263.
3.	Wada, F.; Hirayama, H. Bull. Chem. Soc. Jpn. 1980, 53, 1473-1474.