Molbank 2005, M404

http://www.mdpi.net/molbank/

 

Synthesis of Phenylhydrazone of 5-Acetyl-3-(Methylsulfanyl)-1,2,4-Triazine and 3-Methyl-5-(Methylsulfanyl)-1-Phenyl-1H-Pyrazolo[4,3-e][1,2,4]Triazine from Pivotal Intermediate

 

Mariusz Mojzych

 

Institute of Chemistry, University of Podlasie,

ul. 3 Maja 54, 08-110 Siedlce, Poland

e-mail: [email protected]

 

Received: 23 April 2004 / Accepted: 29 April 2004 / Published: 1 July 2005

 

Keywords: 1,2,4-triazine ketoxime, intramolecular cyclization, 1H-pyrazolo[4,3-e][1,2,4]triazine.

 

As part of ongoing research programme on bicyclic heterocycles [1-4] we have elaborated  a new approach to 1H-pyrazolo[4,3-e][1,2,4]triazine derivative 3 and its synthetic precursor 2 by reaction of oxime 5-acetyl-3-(methylsulfanyl)-1,2,4-triazine (1) with phenylhydrazine hydrochloride under different reaction conditions.

 

 

Phenylhydrazone of 5-acetyl-3-(methylsulfanyl)-1,2,4-triazine 2

 

To a solution of the oxime 1 (184 mg, 1 mmol) and phenylhydrazine hydrochloride (288 mg, 2 mmol) in ethanol (10 ml) 37% HCl (0.3 ml) was added. The mixture was heated at 40 oC for 9 hours and then the solvent was evaporated in vacuo. The solid was collected by filtration, washed with water and recrystallized from ethanol/water mixture (1:1) to give 2 in 27% yield.

 

Melting point: 224 oC.

 

1H-NMR (CDCl3): ¦Ä= 2.30 (s, 3H); 2.69 (s, 3H); 6.99-7.08 (m, 1H); 7.23-7.28 (m, 2H); 7.32-7.41 (m, 2H); 8.05 (s, 1H, NH); 9.63 (s, 1H).

 

IR (KBr, cm-1): 3240 (NH); 2980, 1600, 700.

 

EI-MS (70eV, m/z): 259 (7) [M+]; 147 (45); 129 (100); 112 (54); 70 (90).

 

Elemental Analysis: Calculated for C12H13N5S: C 55.60%; H 5.02%; N 27.03%. Found: C 55.53%; H 5.09%; N 26.99%.

 

3-Methyl ¨C5-(methylsulfanyl)-1-phenyl-1H-pyrazolo[4,3-e][1,2,4]triazine 3

 

To a solution of the oxime 1 (184 mg, 1 mmol) and phenylhydrazine hydrochloride (216 mg, 1.5 mmol) in  ethanol (10 ml) was added 37% HCl (0.3 ml). The mixture was heated at reflux for 5 hours and then the solvent was evaporated in vacuo. The solid was collected by filtration, washed with water and recrystallized from ethanol/water mixture (1:1) to give 3 in 18% yield.   

 

Melting point: 105 oC.

 

1H-NMR (200 MHz, CDCl3): ¦Ä= 2.73 (s, 3H); 2.77 (s, 3H); 7.29-7.40 (m, 1H); 7.50-7.61 (m, 2H); 8.31-8.38 (m, 2H). 

 

IR (KBr, cm-1): 2920, 1590, 1500, 1390, 760.

 

EI-MS (70eV, m/z): 257 (43) [M+]; 232 (3); 216 (22); 93 (41); 77 (100).

 

Elemental Analysis: Calculated for C12H11N5S: C 56.03%; H 4.28%; N 27.23%. Found: C 55.67%; H 4.13%; N 27.05%.

 

References

1. Rykowski, A.; Mojzych, M.; Karczmarzyk, Z. Heterocycles, 2000, 53, 2175.

2. Karczmarzyk, Z.; Mojzych, M.; Rykowski, A., J. Chem. Cryst., 2000, 30, 423.

3. Mojzych, M.; Rykowski, A., Polish J. Chem., 2003, 77, 1797.

4. Mojzych, M.; Rykowski, A., Heterocycles, 2004, (submited).

 

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