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Molbank 2005, M407 |
4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide)
Holger Meining and Baldur Föhlisch*
Institut f邦r Organische Chemie der Universität Stuttgart,
Pfaffenwaldring 55, D-70569 Stuttgart, Germany
Fax: (+ 49) 711/6854269; e-mail: [email protected]
Received:
Keywords: heterocycles, sulfonamides, protective groups
5-Methylfurfurylamine was prepared from commercially available
5-methylfurfural via the oxime, followed by LiAlH4
reduction [1]. A solution of 5-methylfurfurylamine (12.2 g, 100 mmol) in tert-butylmethyl ether[2] (MTBE, 50 mL)
was made in a 250-mL four-necked flask, fitted with two dropping funnels and an
immersion thermometer, and cooled in an ice/salt bath to -15
∼C. With vigorous stirring, solutions of p-toluenesulfonyl chloride (20.97 g, 110 mmol)
in MTBE (80 mL) and 20% aqueous sodium hydroxide (22 mL, 110 mmol) were added
simultaneously and cautiously. The temperatur of the
reaction mixture was not allowed to exceed 每5 ∼C. When the addition was
completed (60每90 min), the cooling bath was removed, and the mixture stirred
for 2每3 hours. The MTBE layer was separated, and the aqueous layer acidified to
pH 3每4 and extracted with MTBE (4 ´ 40 mL). The combined organic solutions were washed with
saturated brine (2 ´ 40 mL)
and dried overnight with magnesium sulfate. After filtration, the solvent was
removed in a rotary evaporator. The remaining pale yellow oil solidified in a
refrigerator. This raw product was recrystallized
from ethanol/pentane (1:1 v/v, 150 mL) to yield 23.44
g (88%) of a colourless crystalline solid.
Melting
Point: 82.5每83.5 ∼C [3].
1H-NMR (250 MHz, CDCl3): 汛= 2.11 (s, 3 H,
5-CH3); 2.41 (s, 3 H, CH3C6H4SO2);
4.10 (d, J = 5.9 Hz, 2 H, CH2-N);
4.98 (t, J = 5.9 Hz, 1 H, NH); AB
sub-spectrum with 汛 A = 5.95, 汛 B = 5.76, JAB = 3.1 Hz, the B part is
split (5 lines, 2 H, H-3 and H-4); AA＊BB＊ sub-spectrum with 汛 A =
7.71, 汛 B = 7.26, JAB
= 8.0 Hz, (4 H, H-2/6 of CH3C6H4SO2, HAA＊ and H-3/5 of CH3C6H4SO2, HBB＊).
13C-NMR (62.9 MHz, CDCl3): 汛= 12.3 (5-CH3);
20.5 (CH3C6H4SO2);
39.2 (CH2-N); 105.15 (C-4); 108.1 (C-3); 126.1 (Tos-C-2/6); 128.5
(Tos-C-3/5); 136.0 (Tos-C-4); 142.3 (Tos-C-1); 146.6 (C-5); 151.2 (C-2).
IR (CHCl3 film, cm-1): 3380, 3280 (NH); 2930, 2880 (C-H); 1598 (C=C); 1555, 1492, 1410,
1330, 1160 cm-1 (SO2).
Elemental
Analysis: Calculated for C13H15NO3S
(265.3): C, 58.85%; H, 5.70%; N, 5.28%; S, 12.08%. Found: C, 58.61%; H, 5.68%;
N, 5.24%; S 12.03%.
References and Notes
1. a) Mndzhoian, A. L.; Afrikian, V. G.; Khorenian, G. A. Izv. Akad. Nauk. Arm. SSR Khim. Nauki 1961, 14, 363每368; Chem. Abstr. 1962, 57, 11136g. b) Mndzhoian, A. L., Synthesis of Heterocyclic Compounds, Vol. 2, p. 60, Consultants Bureau, London, 1959.
2. tert-Butylmethyl ether was recommended as an inexpensive solvent when this experiment was carried out (June 1991, Diploma thesis of H.M.). Nowadays, it is considered environmentally problematic. We also used 1,2-dichloroethane instead of the ether.
3. For a more expensive micro-scale preparation with selective annihilation of contaminants (＆impurity annihilation＊), see: Barrett, A. G. M.; Smith, M. L.; Zecri, F. J. J. Chem. Soc., Chem. Commun. 1998, 2317每2318. However, physical data and combustion analysis are not given in this paper.
Sample Availability: Available from MDPI.
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